Effects of Securigera Securidaca seed extract in combination with glibenclamide on antioxidant capacity, fibroblast growth factor 21 and insulin resistance in hyperglycemic rats

Alizadeh-Fanalou, S. and Babaei, M. and Hosseini, A. and Azadi, N. and Nazarizadeh, A. and Shojaii, A. and Borji, M. and Malekinejad, H. and Bahreini, E. (2020) Effects of Securigera Securidaca seed extract in combination with glibenclamide on antioxidant capacity, fibroblast growth factor 21 and insulin resistance in hyperglycemic rats. Journal of Ethnopharmacology, 248.

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Ethnopharmacological relevance: Undesired effects of synthetic antidiabetic agents have made researchers to seek for safer and healthier resources. With this aspect, herbal materials have attracted substantial research interest and are being extensively investigated. Considering that herb-drug interactions can be a double-edged sword presenting both risks and benefits, investigation of such interactions is greatly in demand. Aim of the study: to investigate possible beneficial effects of hydroalcoholic extract of Securigera Securidaca seed (HESS) on antioxidant capacity, fibroblast growth factor 21 (FGF21) and insulin resistance in Streptozotocin (STZ)-induced diabetic rats, alone and in combination with glibenclamide. Materials and methods: Forty male Wistar rats were randomly divided in to eight equal groups including healthy and diabetic controls and six treated groups with a various doses of HESS alone and in combination with glibenclamide, for 35 consecutive days. Serum samples were taken and analyzed for biochemical profile, HOMA indexes, FGF21, oxidative/nitrosative stress and inflammatory biomarkers as compared with the controls. Moreover, total phenolic and flavonoid contents of herbal extract were assessed. Results: The herbal extract was found to be rich in flavonoid and phenolic components. Both of glibenclamide and the HESS decreased glucose and insulin resistance, as well as increased body weight and insulin sensitivity. Moreover, the extract could mitigate oxidative/nitrosative stress and inflammation dose-dependently, however, the standard drug was less effective than HESS. Induction of diabetes increased FGF21 levels and both of the treatments could reduce its contents, however, glibenclamide was more effective than HESS. Conclusions: The results clearly show that there is no contradiction between HESS and glibenclamide. Moreover, the herbal extract could augment antioxidant and anti-inflammatory properties of the standard drug. © 2019 Elsevier B.V.

Item Type: Article
Additional Information: cited By 1
Uncontrolled Keywords: aryldialkylphosphatase 1; biological marker; C reactive protein; fibroblast growth factor 21; flavonoid; gallic acid; glibenclamide; glucose; glutathione peroxidase; insulin; nitric oxide; phenol derivative; plant extract; quercetin; reactive oxygen metabolite; Securigera Securidaca extract; superoxide dismutase; thiobarbituric acid; unclassified drug; antidiabetic agent; antioxidant; fibroblast growth factor; fibroblast growth factor 21; glibenclamide; plant extract; streptozocin, animal experiment; animal model; animal tissue; antioxidant activity; antioxidant assay; Article; body weight; calibration; controlled study; DPPH radical scavenging assay; drug effect; enzyme linked immunosorbent assay; ferric reducing antioxidant power assay; fluorometry; glucose blood level; herb drug interaction; histopathology; homeostasis model assessment; hyperglycemia; hyperphagia; inflammation; insulin resistance; insulin sensitivity; lipid peroxidation assay; male; nitrosative stress; nonhuman; oxidative stress; plant seed; polydipsia; polyuria; rat; Securigera Securidaca; streptozotocin-induced diabetes mellitus; animal; blood; chemistry; combination drug therapy; experimental diabetes mellitus; Fabaceae; isolation and purification; metabolism; plant seed; Wistar rat, Animals; Antioxidants; Biomarkers; Blood Glucose; Diabetes Mellitus, Experimental; Drug Therapy, Combination; Fabaceae; Fibroblast Growth Factors; Glyburide; Hypoglycemic Agents; Insulin; Insulin Resistance; Male; Oxidative Stress; Plant Extracts; Rats, Wistar; Seeds; Streptozocin
Subjects: WK Endocrine System
Depositing User: eprints admin
Date Deposited: 06 Sep 2020 07:16
Last Modified: 06 Sep 2020 07:16
URI: http://eprints.iums.ac.ir/id/eprint/24061

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