Biological and clinical relevance of metastasis-associated long noncoding RNAs in esophageal squamous cell carcinoma: A systematic review

Talebi, A. and Masoodi, M. and Mirzaei, A. and Mehrad-Majd, H. and Azizpour, M. and Akbari, A. (2020) Biological and clinical relevance of metastasis-associated long noncoding RNAs in esophageal squamous cell carcinoma: A systematic review. Journal of Cellular Physiology, 235 (2). pp. 848-868.

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Esophageal squamous cell carcinoma (ESCC) is a foremost cancer-related death worldwide owing to rapid metastasis and poor prognosis. Metastasis, as the most important reason for death, is biologically a multifaceted process involving a range of cell signaling pathways. Long noncoding RNAs (lncRNAs), as transcriptional regulators, can regulate numerous genomic processes and cellular processes such as cell proliferation, migration, and invasion. LncRNAs have also been shown to involve in/regulate the cancer metastasis-related signaling pathways. Hence, they have increasingly been brought to international attention in molecular oncology research. A number of researchers have attempted to reveal the biological and clinical relevance of lncRNAs in ESCC tumourigenesis and metastasis. The aberrant expression of these molecules in ESCC has regularly been reported to involve in various cellular processes and clinical features, including diagnosis, prognosis, and therapeutic responses. Here, we especially consider the pathways in which lncRNAs act as metastasis-mediated effectors, mainly by interacting with epithelial�mesenchymal transition-associated factors. We review the biological roles of lncRNAs through involving in ESCC metastasis as well as the clinical significance of the metastasis-related lncRNAs in cancer diagnosis and prognosis. © 2019 Wiley Periodicals, Inc.

Item Type: Article
Additional Information: cited By 7
Uncontrolled Keywords: beta elemene; cancer growth factor; cancer susceptibility candidate 9; colon cancer associated transcript 1; complementary RNA; epidermal growth factor receptor 4; growth arrest specific transcript 5; hepatocyte nuclear factor 1alpha; long untranslated RNA; maternally expressed gene 3; plasmacytoma variant translocation 1; small nucleolar RNA; small nucleolar rna host gene 1; small nucleolar rna host gene 16; unclassified drug; x inactive specific transcript protein, cancer diagnosis; cancer growth; cancer prognosis; disease association; epithelial mesenchymal transition; esophageal squamous cell carcinoma; human; metastasis; molecular pathology; overall survival; priority journal; promoter region; Review; signal transduction
Subjects: WI Digestive System
QZ Pathology
Depositing User: eprints admin
Date Deposited: 05 Sep 2020 04:58
Last Modified: 05 Sep 2020 04:58

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