Bagheri Miyab, K. and Alipoor, E. and Vaghardoost, R. and Saberi Isfeedvajani, M. and Yaseri, M. and Djafarian, K. and Hosseinzadeh-Attar, M.J. (2020) The effect of a hydrolyzed collagen-based supplement on wound healing in patients with burn: A randomized double-blind pilot clinical trial. Burns, 46 (1). pp. 156-163.
|
Text
The-effect-of-a-hydrolyzed-collagenbased-supplement-on-wound-healing-in-patients-with-burn-A-randomized-doubleblind-pilot-clinical-trial2020Burns.pdf Download (811kB) | Preview |
Abstract
Introduction: Burn is among the most severe forms of critical illness, associated with extensive and prolonged physical, metabolic and mental disorders. The aim of this study was to assess the effect of an oral, low-cost, and accessible collagen-based supplement on wound healing in patients with burn. Methods: In this randomized double-blind controlled pilot clinical trial, 31 men, 18�60 years, with 20�30 total body surface area burn were studied. Patients were randomly assigned to receive either a collagen-based supplement (1000 kcal) or an isocaloric placebo, for 4 weeks. Serum pre-albumin, rate of wound healing, length of hospital stay, and anthropometries were assessed at baseline, and the end of week 2 and 4. Results: Serum pre-albumin was significantly higher at week 2 (29.7 ± 13.6 vs. 17.8 ± 7.5 mg/dL, P = 0.006) and week 4 (35.1 ± 7.6 vs. 28.3 ± 8.2 mg/dL, P = 0.023) in collagen than control group. Changes in pre-albumin concentration were also significantly higher in collagen group at week 2 (13.9 ± 9.8 vs. �1.9 ± 10.3 mg/dL, P < 0.001) and week 4 (19.2 ± 7.5 vs. 8.5 ± 10.1 mg/dL, P = 0.002). The Hazard ratio of wound healing was 3.7 times in collagen compared to control group (95 CI: 1.434�9.519, P = 0.007). Hospital stay was clinically, but not statistically, lower in collagen than control group (9.4 ± 4.6 vs. 13.5 ± 7 days, P = 0.063). There were no significant differences in weight, body mass index, dietary energy and protein intakes between the two groups. Conclusion: The findings showed that a hydrolyzed collagen-based supplement could significantly improve wound healing and circulating pre-albumin, and clinically reduce hospital stay in patients with 20�30 burn. © 2019 Elsevier Ltd and ISBI
| Item Type: | Article |
|---|---|
| Additional Information: | cited By 1 |
| Uncontrolled Keywords: | collagen; transthyretin, adult; albumin blood level; Article; body mass; body surface; body weight; burn; caloric intake; clinical article; controlled study; double blind procedure; drug effect; hospitalization; human; hydrolysis; length of stay; male; middle aged; pilot study; protein intake; randomized controlled trial; supplementation; surgical debridement; wound healing; young adult |
| Subjects: | WO Surgery |
| Depositing User: | eprints admin |
| Date Deposited: | 05 Sep 2020 04:18 |
| Last Modified: | 05 Sep 2020 04:18 |
| URI: | http://eprints.iums.ac.ir/id/eprint/24135 |
Actions (login required)
 |
View Item |
