Asbaghi, O. and Nazarian, B. and Reiner, Ž. and Amirani, E. and Kolahdooz, F. and Chamani, M. and Asemi, Z. (2020) The effects of grape seed extract on glycemic control, serum lipoproteins, inflammation, and body weight: A systematic review and meta-analysis of randomized controlled trials. Phytotherapy Research, 34 (2). pp. 239-253.
Full text not available from this repository.Abstract
The aim of this systematic review and meta-analysis was to analyze the effects of grape seed extract (GSE) on glycemic control and serum lipoproteins, inflammation and body weight. Two independent authors systematically searched online databases including EMBASE, Scopus, PubMed, Cochrane Library, and Web of Science from inception until May 30, 2019. Cochrane Collaboration risk of bias tool was applied to assess the methodological quality of included trials. The heterogeneity among the included studies was assessed using Cochrane's Q test and I-square (I2) statistic. Data were pooled using a random-effects model and weighted mean difference (WMD) was considered as the overall effect size. Fifty trials were included in this meta-analysis. Pooling effect sizes from studies demonstrated a significant decrease in fasting plasma glucose (FPG) (WMD): �2.01; 95 confidence interval (CI): �3.14, �0.86), total cholesterol (TC; WMD: �6.03; 95 CI: �9.71, �2.35), low-density lipoprotein (LDL) cholesterol (WMD: �4.97; 95 CI: �8.37, �1.57), triglycerides (WMD: �6.55; 95 CI: �9.28, �3.83), and C-reactive protein (CRP) concentrations (WMD: �0.81; 95 CI: �1.25, �0.38) following GSE therapy. Grape seed did not influence HbA1c, HDL cholesterol levels, and anthropometric measurements. This meta-analysis demonstrated that GSE intake significantly reduced FPG, TC, LDL cholesterol, triglycerides, and CRP levels. © 2019 John Wiley & Sons, Ltd.
| Item Type: | Article |
|---|---|
| Additional Information: | cited By 1 |
| Uncontrolled Keywords: | C reactive protein; grape seed extract; hemoglobin A1c; lipoprotein; low density lipoprotein cholesterol; placebo; proanthocyanidin; triacylglycerol; C reactive protein; cholesterol; grape seed extract; lipoprotein; low density lipoprotein cholesterol; triacylglycerol, antidiabetic activity; antiinflammatory activity; antioxidant activity; body weight; cholesterol blood level; drug activity; drug efficacy; genetic heterogeneity; glucose blood level; glycemic control; health status; hemoglobin blood level; human; inflammation; lipoprotein blood level; low density lipoprotein cholesterol level; meta analysis; nonhuman; protein blood level; protein expression; randomized controlled trial (topic); Review; systematic review; triacylglycerol blood level; blood; glucose blood level; inflammation, Blood Glucose; Body Weight; C-Reactive Protein; Cholesterol; Cholesterol, LDL; Grape Seed Extract; Humans; Inflammation; Lipoproteins; Randomized Controlled Trials as Topic; Triglycerides |
| Subjects: | WB Practice of Medicine WK Endocrine System |
| Depositing User: | eprints admin |
| Date Deposited: | 02 Sep 2020 09:41 |
| Last Modified: | 02 Sep 2020 09:41 |
| URI: | http://eprints.iums.ac.ir/id/eprint/24149 |
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