Metal-Based Nanostructures/PLGA Nanocomposites: Antimicrobial Activity, Cytotoxicity, and Their Biomedical Applications

Zare, E.N. and Jamaledin, R. and Naserzadeh, P. and Afjeh-Dana, E. and Ashtari, B. and Hosseinzadeh, M. and Vecchione, R. and Wu, A. and Tay, F.R. and Borzacchiello, A. and Makvandi, P. (2020) Metal-Based Nanostructures/PLGA Nanocomposites: Antimicrobial Activity, Cytotoxicity, and Their Biomedical Applications. ACS Applied Materials and Interfaces, 12 (3). pp. 3279-3300.

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Among the different synthetic polymers developed for biomedical applications, poly(lactic-co-glycolic acid) (PLGA) has attracted considerable attention because of its excellent biocompatibility and biodegradability. Nanocomposites based on PLGA and metal-based nanostructures (MNSs) have been employed extensively as an efficient strategy to improve the structural and functional properties of PLGA polymer. The MNSs have been used to impart new properties to PLGA, such as antimicrobial properties and labeling. In the present review, the different strategies available for the fabrication of MNS/PLGA nanocomposites and their applications in the biomedical field will be discussed, beginning with a description of the preparation routes, antimicrobial activity, and cytotoxicity concerns of MNS/PLGA nanocomposites. The biomedical applications of these nanocomposites, such as carriers and scaffolds in tissue regeneration and other therapies are subsequently reviewed. In addition, the potential advantages of using MNS/PLGA nanocomposites in treatment illnesses are analyzed based on in vitro and in vivo studies, to support the potential of these nanocomposites in future research in the biomedical field. © 2019 American Chemical Society.

Item Type: Article
Additional Information: cited By 15
Uncontrolled Keywords: Biocompatibility; Biodegradability; Biodegradable polymers; Cytotoxicity; Medical applications; Microorganisms; Nanocomposites; Nanostructures; Scaffolds (biology); Tissue regeneration, Anti-microbial activity; Anti-microbial properties; Antimicrobial activity , cytotoxicity; Biomedical applications; Functional properties; PLGA; Poly(lactic-co-glycolic acid); Synthetic polymers, Functional polymers
Subjects: QU Biochemistry. Cell Biology and Genetics
Depositing User: eprints admin
Date Deposited: 02 Sep 2020 07:09
Last Modified: 02 Sep 2020 07:09

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