Progress in Conductive Polyaniline-Based Nanocomposites for Biomedical Applications: A Review

Zare, E.N. and Makvandi, P. and Ashtari, B. and Rossi, F. and Motahari, A. and Perale, G. (2020) Progress in Conductive Polyaniline-Based Nanocomposites for Biomedical Applications: A Review. Journal of Medicinal Chemistry, 63 (1). pp. 1-22.

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Inherently conducting polymers (ICPs) are a specific category of synthetic polymers with distinctive electro-optic properties, which involve conjugated chains with alternating single and double bonds. Polyaniline (PANI), as one of the most well-known ICPs, has outstanding potential applications in biomedicine because of its high electrical conductivity and biocompatibility caused by its hydrophilic nature, low-toxicity, good environmental stability, and nanostructured morphology. Some of the limitations in the use of PANI, such as its low processability and degradability, can be overcome by the preparation of its blends and nanocomposites with various (bio)polymers and nanomaterials, respectively. This review describes the state-of-the-art of biological activities and applications of conductive PANI-based nanocomposites in the biomedical fields, such as antimicrobial therapy, drug delivery, biosensors, nerve regeneration, and tissue engineering. The latest progresses in the biomedical applications of PANI-based nanocomposites are reviewed to provide a background for future research. © 2019 American Chemical Society.

Item Type: Article
Additional Information: cited By 27
Uncontrolled Keywords: cholesterol; hydrogen peroxide; nanocomposite; phenol derivative; polyaniline; aniline derivative; antiinfective agent; antioxidant; biodegradable plastic; biomaterial; drug carrier; nanocomposite; polyaniline, antimicrobial activity; antimicrobial therapy; antioxidant activity; biocompatibility; biological activity; drug cytotoxicity; drug degradation; drug delivery system; drug structure; drug synthesis; human; nonhuman; physical chemistry; Review; tissue engineering; animal; chemistry; electric conductivity; genetic procedures; procedures; synthesis; tumor cell line, Aniline Compounds; Animals; Anti-Bacterial Agents; Antioxidants; Biocompatible Materials; Biodegradable Plastics; Biosensing Techniques; Cell Line, Tumor; Drug Carriers; Electric Conductivity; Humans; Nanocomposites; Tissue Engineering
Subjects: QT Physiology
Depositing User: eprints admin
Date Deposited: 02 Sep 2020 05:36
Last Modified: 02 Sep 2020 05:36

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