The Effects of Synbiotic Supplementation on Antioxidant Capacity and Arm Volumes in Survivors of Breast Cancer-Related Lymphedema

Navaei, M. and Haghighat, S. and Janani, L. and Vafa, S. and Saneei Totmaj, A. and Raji Lahiji, M. and Emamat, H. and Salehi, Z. and Amirinejad, A. and Izad, M. and Zarrati, M. (2020) The Effects of Synbiotic Supplementation on Antioxidant Capacity and Arm Volumes in Survivors of Breast Cancer-Related Lymphedema. Nutrition and Cancer, 72 (1). pp. 62-73.

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Background and Aims: Synbiotics found to be beneficial in breast cancer survivors (BCSs) through its antioxidant properties. The aim of this study was to assess the effects of synbiotic supplementation on edema volume and some oxidative markers among obese and overweight patients with BCRL. Method: This randomized double-blind, placebo-controlled trial was conducted on 88 overweight and obese BCSs aged 18�65 years. All the subjects were given a specified low-calorie diet (LCD) and were randomly assigned into two groups to intake 109 CFU/day synbiotic supplement (n = 44) or placebo (n = 44) for 10 wk. Edema volume and serum total antioxidant capacity (TAC), malondialdehyde (MDA), glutathione peroxidase (GPx), and superoxide dismutase (SOD) concentration were measured at baseline and after the 10-wk intervention. Results: Ten-wk supplementation with synbiotics leads to a significant reduction in serum MDA levels (P = 0.001) and an increase in serum SOD concentration (P = 0.007) compared to placebo. No significant changes were observed in serum GPx, TAC, and edema volume between groups. Conclusion: Our findings reveal that 10-wk synbiotic supplementation along with a LCD program-reduced serum MDA levels and elevate the activity of SOD in overweight and obese patients with BCRL. However, its effect on serum GPx, TAC, and edema volume was not significant. © 2019, © 2019 Iran University of Medical Sciences.

Item Type: Article
Additional Information: cited By 1
Uncontrolled Keywords: glutathione peroxidase; lactocare; malonaldehyde; placebo; superoxide dismutase; synbiotic agent, adult; aged; Article; bacteriotherapy; breast cancer-related lymphedema; cancer survivor; controlled study; double blind procedure; female; human; low calorie diet; major clinical study; obese patient; protein blood level; randomized controlled trial; supplementation
Subjects: WP Gynecology
Depositing User: eprints admin
Date Deposited: 02 Sep 2020 03:58
Last Modified: 02 Sep 2020 03:58

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