Targeting mTOR signaling by polyphenols: A new therapeutic target for ageing

Pazoki-Toroudi, H. and Amani, H. and Ajami, M. and Nabavi, S.F. and Braidy, N. and Kasi, P.D. and Nabavi, S.M. (2016) Targeting mTOR signaling by polyphenols: A new therapeutic target for ageing. Ageing Research Reviews, 31. pp. 55-66.

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Abstract

Current ageing research is aimed not only at the promotion of longevity, but also at improving �health span� through the� discovery and development� of new therapeutic strategies��� by investigating �molecular and �cellular �pathways involved in cellular senescence.� Understanding the mechanism of action �of �polyphenolic compounds targeting mTOR (mechanistic target of rapamycin) and related pathways opens up new directions ��to revolutionize ways to slow down the �onset and development of age-dependent degeneration. Herein, we will �discuss the mechanisms by which polyphenols can delay the� molecular �pathogenesis of ageing via manipulation or more specifically inhibition of mTOR-signaling pathways. We will also discuss the implications of polyphenols in targeting mTOR and its related �pathways�� on �health life span extension and longevity.� © 2016 Elsevier B.V.

Item Type: Article
Additional Information: cited By 12
Depositing User: eprints admin
Date Deposited: 08 Jul 2018 03:37
Last Modified: 08 Jul 2018 03:37
URI: http://eprints.iums.ac.ir/id/eprint/3117

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