Multifunctional hydrogels for wound healing: Special focus on biomacromolecular based hydrogels

Asadi, N. and Pazoki-Toroudi, H. and Del Bakhshayesh, A.R. and Akbarzadeh, A. and Davaran, S. and Annabi, N. (2021) Multifunctional hydrogels for wound healing: Special focus on biomacromolecular based hydrogels. International Journal of Biological Macromolecules, 170. pp. 728-750.

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Hydrogels are widely used for wound healing applications due to their similarity to the native extracellular matrix (ECM) and ability to provide a moist environment. However, lack of multifunctionality and low mechanical properties of previously developed hydrogels may limit their ability to support skin tissue regeneration. Incorporating various biomaterials and nanostructures into the hydrogels is an emerging approach to develop multifunctional hydrogels with new functions that are beneficial for wound healing. These multifunctional hydrogels can be fabricated with a wide range of functions and properties, including antibacterial, antioxidant, bioadhesive, and appropriate mechanical properties. Two approaches can be used for development of multifunctional hydrogel-based dressings; taking the advantages of the chemical composition of biomaterials and addition of nanomaterials or nanostructures. A large number of synthetic and natural polymers, bioactive molecules, or nanomaterials have been used to obtain hydrogel-based dressings with multifunctionality for wound healing applications. In the present review paper, advances in the development of multifunctional hydrogel-based dressings for wound healing have been highlighted. © 2020 Elsevier B.V.

Item Type: Article
Additional Information: cited By 0
Subjects: QV Pharmacology
Depositing User: eprints admin
Date Deposited: 14 Mar 2021 10:23
Last Modified: 14 Mar 2021 10:23

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