Saatchi, A. and Arani, A.R. and Moghanian, A. and Mozafari, M. (2021) Synthesis and characterization of electrospun cerium-doped bioactive glass/chitosan/polyethylene oxide composite scaffolds for tissue engineering applications. Ceramics International, 47 (1). pp. 260-271.
Full text not available from this repository.Abstract
In this study, a series of electrospun chitosan/polyethylene oxide (PEO) nanofibrous scaffolds containing different amount of cerium-doped bioactive glasses (Ce-BGs) have been fabricated and proposed for tissue engineering applications. On a biological level, higher 8Ce-BG content significantly improved cytocompatibility of the scaffolds. Moreover, results of fibroblast cell culture study showed that greater 8Ce-BG content could enhance cell attachment and cell expansion on fiber mesh. Characterization of the scaffolds revealed that increasing 8Ce-BG content caused bioactive glass nanoparticles to agglomerate at a higher rate. The SEM mapping revealed thorough dispersion of submicrometric clusters in all areas of the polymeric matrix. Contact angle measurements showed that increasing 8Ce-BG/CH ratio from 0 to 10 (wt.) improved wettability of the scaffold significantly. However, by increasing the ratio beyond 10 (wt.), the wettability values decreased gradually. In conclusion, it was found that increasing 8Ce-BG/CH weight ratio up to 40 (wt.) in the scaffold system was practical and useful for soft tissue engineering applications. © 2020 Elsevier Ltd and Techna Group S.r.l.
| Item Type: | Article |
|---|---|
| Additional Information: | cited By 5 |
| Uncontrolled Keywords: | Bioactive glass; Cell culture; Contact angle; Tissue; Wetting, Cytocompatibility; Fibroblast cells; Nanofibrous scaffolds; Oxide composites; Polymeric matrices; Soft tissue engineering; Synthesis and characterizations; Tissue engineering applications, Scaffolds (biology) |
| Subjects: | QS Human Anatomy |
| Depositing User: | eprints admin |
| Date Deposited: | 11 Apr 2021 05:18 |
| Last Modified: | 11 Apr 2021 05:18 |
| URI: | http://eprints.iums.ac.ir/id/eprint/33262 |
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