The effects of omega-3 fatty acids supplementation on metabolic status in pregnant women: a systematic review and meta-analysis of randomized controlled trials

Amirani, E. and Asemi, Z. and Asbaghi, O. and Milajerdi, A. and Reiner, Ž. and Mansournia, M.A. and Hallajzadeh, J. and Moazzami, B. and Chaichian, S. (2020) The effects of omega-3 fatty acids supplementation on metabolic status in pregnant women: a systematic review and meta-analysis of randomized controlled trials. Journal of Diabetes and Metabolic Disorders, 19 (2). pp. 1685-1699.

Preview

Text The effects of omega-3 fatty acids supplementation on metabolic status in pregnant women a systematic review and meta-analysis of randomized controlled trials.pdf Download (710kB) | Preview

Abstract

Background and objective: Data regarding the effects of omega-3 polyunsaturated fatty acids (PUFA) supplementation on metabolic status of pregnant women are limited. This systematic review and meta-analysis were done based on randomized controlled trials (RCTs) dealing with the effects of omega-3 PUFA supplementation on glycemic control, lipoproteins, inflammation and oxidative stress in pregnant women. Methods: Following databases were searched for eligible studies published from inception to until 2019: MEDLINE, EMBASE, Web of Science, PubMed, Scopus, Cochrane Library, and Google scholar. Studies that evaluated the effect of omega-3 PUFA supplementation on parameters of glycemic control, lipoproteins, inflammation and oxidative stress in pregnant women were found by using the key MeSH. A study quality assessment was performed using the Cochrane Collaboration risk of bias tool and heterogeneity between studies was statistically computed using Cochrane�s Q test and I-square (I2). Data were pooled using a random-effects model and weighted mean difference (WMD) was considered as the overall effect size. Results: No significant effects of omega-3 PUFA supplementation on FPG, insulin, insulin resistance, total cholesterol, triglycerides, LDL-cholesterol, total cholesterol/HDL-cholesterol, interleukin 6 (IL-6), IL-8, and malondialdehyde were found. However, omega-3 PUFA significantly increased serum concentrations of HDL-cholesterol (WMD: 3.10; 95 CI: 0.18, 6.03) and reduced C-reactive protein (WMD: -1.85; 95 CI: -2.61, -1.09). Conclusion: Based on the results of this meta-analysis omega-3 PUFA supplementation during pregnancy has a significant beneficial effect on HDL-cholesterol, and C-reactive protein. © 2020, Springer Nature Switzerland AG.

Actions (login required)

View Item