KHOSHBAYAN, A. and SHARIATI, A. and GHAZNAVI-RAD, E. and VAN BELKUM, A. and ARBAN-SAROKHALIL, D. (2020) Prevalence and molecular epidemiology of ceftaroline non-susceptible methicillin-resistant Staphylococcus aureus isolates, first clinical report from Iran. Acta Microbiologica et Immunologica Hungarica, 67 (4). pp. 228-233.
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Prevalence-and-molecular-epidemiology-of-ceftaroline-nonsusceptible-methicillinresistant-Staphylococcus-aureus-isolates-first-clinical-report-from-Iran2020Acta-Microbiologica-et-Immunologica-Hungarica.pdf Download (665kB) | Preview |
Abstract
Background: Methicillin-resistant Staphylococcus aureus (MRSA) is one of the major pathogens in Iran with a high prevalence and a high level of antibiotic resistance. Ceftaroline is a fifth generation cephalosporin binding and inhibiting penicillin binding protein (PBP2a). Methods: In the present study, 228 clinical MRSA isolates were collected from four cities of Iran and their susceptibility to ceftaroline was evaluated by E-test and the disk diffusion method. Results: Our results showed a high susceptibility rate (97.3) to ceftaroline in MRSA strains from Iran. Six isolates were found to be ceftaroline non-susceptible (CPT-NS) with Minimum inhibitory concentration (MIC) �2 mg/mL. All CPT-NS isolates were isolated from blood and tracheal aspirate and belonged to SCCmec type III as well as agr type I and were all susceptible to vancomycin. Out of six isolates, three, two and one belonged to spa type t030, t4864, and t969, respectively. Vancomycin, quinupristin/dalfopristin, linezolid, chloramphenicol, and tigecycline were the most active agents against CPT-NS isolates. Conclusion: Due to the broad-spectrum activity and low toxicity of ceftaroline as well as the increased rate of vancomycin resistance among MRSA strains in recent years, ceftaroline can be considered as a novel approach to treat MRSA-induced infections. © 2020 The Author(s).
| Item Type: | Article |
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| Additional Information: | cited By 0 |
| Uncontrolled Keywords: | cefepime; cefixime; ceftaroline; chloramphenicol; ciprofloxacin; clindamycin; cotrimoxazole; dalfopristin plus quinupristin; erythromycin; gentamicin; imipenem; linezolid; nitrofurantoin; norfloxacin; penicillin G; rifampicin; tetracycline; tigecycline; vancomycin, antibiotic sensitivity; Article; bacterial strain; bacterium isolate; blood sampling; disk diffusion; epsilometer test; gene; Iran; methicillin resistant Staphylococcus aureus; methicillin resistant Staphylococcus aureus infection; minimum inhibitory concentration; molecular epidemiology; molecular typing; nonhuman; prevalence; spa gene; tracheal aspiration procedure; vancomycin resistance |
| Subjects: | QV Pharmacology |
| Depositing User: | eprints admin |
| Date Deposited: | 11 May 2021 04:06 |
| Last Modified: | 11 May 2021 04:06 |
| URI: | http://eprints.iums.ac.ir/id/eprint/33551 |
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