Nanomaterial integration into the scaffolding materials for nerve tissue engineering: a review

Arzaghi, H. and Adel, B. and Jafari, H. and Askarian-Amiri, S. and Shiralizadeh Dezfuli, A. and Akbarzadeh, A. and Pazoki-Toroudi, H. (2020) Nanomaterial integration into the scaffolding materials for nerve tissue engineering: a review. Reviews in the Neurosciences, 31 (8). pp. 843-872.


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The nervous system, which consists of a complex network of millions of neurons, is one of the most highly intricate systems in the body. This complex network is responsible for the physiological and cognitive functions of the human body. Following injuries or degenerative diseases, damage to the nervous system is overwhelming because of its complexity and its limited regeneration capacity. However, neural tissue engineering currently has some capacities for repairing nerve deficits and promoting neural regeneration, with more developments in the future. Nevertheless, controlling the guidance of stem cell proliferation and differentiation is a challenging step towards this goal. Nanomaterials have the potential for the guidance of the stem cells towards the neural lineage which can overcome the pitfalls of the classical methods since they provide a unique microenvironment that facilitates cell-matrix and cell-cell interaction, and they can manipulate the cell signaling mechanisms to control stem cells' fate. In this article, the suitable cell sources and microenvironment cues for neuronal tissue engineering were examined. Afterward, the nanomaterials that impact stem cell proliferation and differentiation towards neuronal lineage were reviewed. © 2020 Hamidreza Arzaghi et al., published by De Gruyter, Berlin/Boston 2020.

Item Type: Article
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Uncontrolled Keywords: brain derived neurotrophic factor; carbon nanotube; chitosan; collagen; fibrin; fibroblast growth factor 2; fibroblast growth factor 8; gelatin; gold nanoparticle; graphene; macrogol; nanomaterial; nerve growth factor; neurotrophin 3; Notch receptor; poly(isobutyl 2 cyanoacrylate); polyacrylonitrile; polycaprolactone; polyglactin; polypyrrole; polyurethan; silk fibroin; silver nanoparticle; Smad protein; sonic hedgehog protein; titanium dioxide; ultrasmall superparamagnetic iron oxide; vasculotropin; Wnt protein, Article; biocompatibility; body movement; cell differentiation; cell fate; cell interaction; cell lineage; cell proliferation; cognition; dental pulp stem cell; drug delivery system; embryonic stem cell; extracellular matrix; human; induced pluripotent stem cell; mesenchymal stem cell; microenvironment; nerve cell; nerve cell differentiation; nerve cell network; nerve regeneration; nervous system injury; nervous tissue; neural stem cell; nonhuman; Notch signaling; priority journal; protein expression; protein secretion; signal transduction; skeletal muscle derived stem cell; skin derived stem cell; stem cell; stem cell transplantation; tissue engineering; Wnt signaling
Subjects: QS Human Anatomy
Depositing User: eprints admin
Date Deposited: 16 May 2021 04:22
Last Modified: 16 May 2021 04:22

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