Prognostic role and therapeutic susceptibility of cathepsin in various types of solid tumor and leukemia: A systematic review

Hadad, E.H. and Ahmadzadeh, A. and Abooali, A. and Saki Malehi, A. and Shokouhian, M. and Saki, N. (2020) Prognostic role and therapeutic susceptibility of cathepsin in various types of solid tumor and leukemia: A systematic review. Journal of Cellular Physiology, 235 (11). pp. 7709-7730.

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Cathepsins (CTSs) are multifunctional proteins that can play prominent roles in cancer progression and metastasis. In this systematic review, we compared the prognosis of CTS subtypes overexpression in leukemia and solid tumors, and investigated the effect of different factors on CTS prognosis. We systematically searched published articles indexed in PubMed, Scopus, Cochrane library, ISI Web of Science, and EmBase databases from February 2000 until January 2020. Among the selected leukemia and solid tumors studies, overexpression of CTS subtypes in newly diagnosed and treated patients were with poor prognosis in 43 studies (79.6) and with good prognosis in 9 studies (16.6). However, there were 2 studies (3.8) with either good or poor prognosis, depending on conditions and caner stage and host cell. The relation between CTS and human leukocyte antigen (HLA) in leukemia and solid tumors was mentioned in 7 studies (13). Overexpression of CTS subtypes in all new case patients had contributed to the induction of poor prognosis. It seems that CTS subtypes, based on the type of cancer and its stage, the type of host cells, and the probable relation with HLA, breed good or poor prognosis in patients with cancer. Therefore, monitoring the overexpression of CTS subtypes and determining the effect of each of these factors on CTS prognosis could be helpful in predicting cancer prognosis both in newly diagnosed or under treatment patients. They could also be useful in finding ways for improving the efficiency of contemporary therapeutic strategies in various types of leukemia and solid tumors. © 2020 Wiley Periodicals, Inc.

Item Type: Article
Additional Information: cited By 0
Uncontrolled Keywords: aspartic proteinase; cathepsin; cysteine proteinase; HLA antigen; serine proteinase, cancer prognosis; cancer staging; host cell; human; leukemia; Preferred Reporting Items for Systematic Reviews and Meta-Analyses; priority journal; Review; solid malignant neoplasm; systematic review
Subjects: WH Hemic and Lymphatic Systems
QV Pharmacology
QZ Pathology
Depositing User: eprints admin
Date Deposited: 28 Jun 2021 08:13
Last Modified: 28 Jun 2021 08:13

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