The relationship between serum adipokines and glucose homeostasis in normal-weight and obese patients on hemodialysis: a preliminary study

Alipoor, E. and Yaseri, M. and Mehrdadi, P. and Mahdavi-Mazdeh, M. and Murphy, T. and Hosseinzadeh-Attar, M.J. (2020) The relationship between serum adipokines and glucose homeostasis in normal-weight and obese patients on hemodialysis: a preliminary study. International Urology and Nephrology, 52 (11). pp. 2179-2187.

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Purpose: Insulin resistance (IR) is a prevalent disorder in advanced renal failure irrespective of diabetes. Adipokines might play a role in IR, which has not been well-documented in uremic conditions. This study investigated the relationship of Zinc-α2-glycoprotein (ZAG), adipose triglyceride lipase (ATGL), and adipolin with glucose�insulin homeostasis in normal weight (NW) and obese (OB) patients with hemodialysis. Methods: In this cross-sectional study, 59 patients (29 NW; 18.5 � BMI < 25 kg/m2, and 30 OB; BMI � 30 kg/m2) were studied. Anthropometries, circulating ZAG, adipolin, ATGL, free fatty acids (FFAs), fasting blood glucose (FBG), insulin, and homeostasis model assessment of IR (HOMA)-IR were assessed. Results: There were no significant differences in age, gender, hemodialysis duration, dialysis adequacy and diabetes between the two groups. ZAG (100.9 ± 37.1 vs. 107.5 ± 30.5 ng/mL, P = 0.03) and adipolin (12.4 ± 1.6 vs. 13.2 ± 2.8 ng/mL, P = 0.002) concentrations were significantly lower, and FFAs (228.1 ± 112.6 vs. 185 ± 119 ng/mL, P = 0.014) were significantly higher in the OB than NW group. No significant differences were observed in ATGL, FBG, insulin and HOMA-IR between the two groups. Patients with lower IR had higher ZAG (112.9 ± 31.7 vs. 94.9 ± 34.5 ng/mL; P = 0.046), lower FFAs (167.8 ± 98.4 vs. 249.9 ± 120.8 ng/mL; P = 0.004), and marginally lower ATGL (9.1 ± 5.2 vs. 12.3 ± 9.6 mIU/mL; P = 0.079) concentrations than those with higher IR. ZAG was negatively (r = � 0.323, P = 0.018 and r = � 0.266, P = 0.054) and FFAs were positively (r = 0.321, P = 0.019 and r = 0.353, P = 0.009) correlated with insulin and HOMA-IR, respectively. ATGL was directly correlated with FFAs (r = 0.314, P = 0.018). Conclusions: Novel adipokines, ZAG and ATGL, might contribute to glucose�insulin homeostasis in hemodialysis. Understanding potential causative, diagnostic or therapeutic roles of adipokines in IR require further studies. © 2020, Springer Nature B.V.

Item Type: Article
Additional Information: cited By 0
Uncontrolled Keywords: adipocytokine; adipolin; albumin; alpha2 glycoprotein; C reactive protein; fatty acid; high density lipoprotein; insulin; low density lipoprotein; triacylglycerol; triacylglycerol lipase; unclassified drug; Zinc alpha 2 glycoprotein, adult; anthropometry; Article; body mass; body weight; concentration (parameter); controlled study; cross-sectional study; fasting; female; glucose blood level; glucose homeostasis; hemodialysis; HOMA index; human; iron binding capacity; major clinical study; male; middle aged; obese patient; protein blood level
Subjects: WD Disorders of Systemic, Metabolic or Environmental Origin, etc.
WJ Urogenital System
Depositing User: eprints admin
Date Deposited: 27 Jun 2021 06:11
Last Modified: 27 Jun 2021 06:11

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