Effect of melatonin supplementation on oxidative stress parameters: A systematic review and meta-analysis

Morvaridzadeh, M. and Sadeghi, E. and Agah, S. and Nachvak, S.M. and Fazelian, S. and Moradi, F. and Persad, E. and Heshmati, J. (2020) Effect of melatonin supplementation on oxidative stress parameters: A systematic review and meta-analysis. Pharmacological Research, 161.

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Official URL: https://www.scopus.com/inward/record.uri?eid=2-s2....


Background: Oxidative stress, defined as an imbalance between pro-oxidants and neutralizing antioxidants within the body, is a growing public health concern. Oxidative stress is involved in the progression of nearly all chronic diseases. Melatonin has been suggested to reduce oxidative stress by its potential radical scavenging properties. Objective: To determine the efficacy and safety of melatonin as a therapy for the improvement of oxidative stress parameters in randomized controlled trials. Methods: A systematic database search using Scopus, PubMed/Medline, EMBASE, Web of Science, the Cochrane Controlled Register of Trials and clinicaltrials.gov (https://clinicaltrials.gov) for studies published up to July 2020 was conducted. We included studies which investigated the effect of supplemental melatonin compared to placebo on oxidative stress parameters in unhealthy patients. Quantitative data synthesis was conducted using a random-effects model with standard mean difference (SMD) and 95 confidence intervals (CI). Cochrane's Q and I2 values were used to evaluate heterogeneity. Results: A total of 12 randomized controlled trials (RCTs) were eligible. The meta-analysis indicated an association between melatonin intake and a significant increase in total antioxidant capacity (TAC) (SMD: 0.76; 95 CI: 0.30, 1.21; I2 = 80.1 ), glutathione (GSH) levels (SMD: 0.57; 95 CI: 0.32, 0.83; I2 = 15.1 ), superoxide dismutase (SOD) (SMD: 1.38; 95 CI: 0.13, 2.62; I2 = 86.9 ), glutathione peroxidase (GPx) (SMD: 1.36; 95 CI: 0.46, 2.30; I2 = 89.3 ), glutathione reductase (GR) (SMD: 1.21; 95 CI: 0.65, 1.77; I2 = 00.0 ) activities, and a significant reduction in malondialdehyde (MDA) levels (SMD: -0.79; 95 CI: -1.19, -0.39; I2 = 73.1 ). Melatonin intake was not shown to significantly affect nitric oxide (NO) levels (SMD: -0.24; 95 CI: -0.61, 0.14; I2 = 00.0 ) or catalase (CAT) activity (SMD: -1.38; 95 CI: -1.42, 4.18; I2 = 96.6 ). Conclusion: Melatonin intake was shown to have a significant impact on improving Oxidative stress parameters. However, future research through large, well-designed randomized controlled trials are required to determine the effect of melatonin on oxidative stress parameters in different age groups and different disease types. © 2020 Elsevier Ltd

Item Type: Article
Additional Information: cited By 1
Uncontrolled Keywords: catalase; glutathione; glutathione peroxidase; glutathione reductase; malonaldehyde; melatonin; nitric oxide; placebo; superoxide dismutase, antioxidant activity; Article; drug effect; drug efficacy; drug safety; enzyme activity; enzyme analysis; human; meta analysis; metabolic parameters; monotherapy; oxidative stress; parallel design; priority journal; quantitative study; randomized controlled trial (topic); supplementation; systematic review; treatment response
Subjects: WM Psychiatry
QV Pharmacology
Depositing User: eprints admin
Date Deposited: 27 Jun 2021 03:31
Last Modified: 27 Jun 2021 03:31
URI: http://eprints.iums.ac.ir/id/eprint/33822

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