Evaluation of patients with primary immunodeficiency associated with Bacille Calmette-Guerin (BCG)-vaccine-derived complications

Sohani, M. and Habibi, S. and Delavari, S. and Shahkarami, S. and Yazdani, R. and Shirmast, P. and Nazari, F. and Moeini Shad, T. and Mamishi, S. and Azizi, G. and Anka, A.U. and Hassanpour, G. and Kalantari, A. and Shariat, M. and Shafiei, A. and Abolhassani, H. and Aghamohammadi, A. (2020) Evaluation of patients with primary immunodeficiency associated with Bacille Calmette-Guerin (BCG)-vaccine-derived complications. Allergologia et Immunopathologia, 48 (6). pp. 729-737.

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Background: Bacille Calmette-Guerin (BCG) vaccination has a great impact on the prevention of severe complications of tuberculosis. However, in patients with primary immunodeficiencies (PID), it can lead to severe complications such as severe combined immunodeficiency, chronic granulomatous disease, and Mendelian susceptibility to mycobacterial disease. This study highlights the demographics, clinical complications and laboratory parameters among PID patients associated with BCG vaccination side effects. Methods: One hundred and thirty-seven PID patients with BCGosis were evaluated in this study, based on the complications following BCG vaccination. Results: The mean age of the patients with BCG complications at the time of the first visit was five years. The within-group comparison of patients showed a highly significant incidence of pneumonia and hepatomegaly in severe combined immunodeficiency patients. Furthermore, the immunologic data showed an increase in the overall rates of lymphocytes such as CD3+, CD4+ and CD8 + T cells in Mendelian susceptibility to mycobacterial disease patients. The level of immunoglobulins has also increased in chronic granulomatous disease patients. Conclusion: The high rate of undiagnosed PIDs predisposes individuals to a high risk of severe side effects as a result of BCG vaccination, as well as infants that are less than one month of age. Therefore, there is a need for early screening and diagnosis of PIDs before exposing unknown PID status patients to BCG vaccination. The benefits of screening and early diagnosis of PID cannot be overemphasized, especially in patients with a previous family history of immunodeficiency. © 2020 SEICAP

Item Type: Article
Additional Information: cited By 0
Uncontrolled Keywords: BCG vaccine; immunoglobulin, adverse drug reaction; Article; BCG vaccination; CD3+ T lymphocyte; CD4+ T lymphocyte; CD8+ T lymphocyte; child; chronic granulomatous disease; controlled study; disease predisposition; female; hepatomegaly; human; human cell; immune deficiency; immunoglobulin blood level; infant; major clinical study; male; mycobacteriosis; newborn; pneumonia; severe combined immunodeficiency
Subjects: QV Pharmacology
QW Microbiology. Immunology
Depositing User: eprints admin
Date Deposited: 26 Jun 2021 03:44
Last Modified: 26 Jun 2021 03:44
URI: http://eprints.iums.ac.ir/id/eprint/33831

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