Synthesis and Anticancer Activity of N-(di/trimethoxyaryl)-5-arylisoxazole-3-carboxamide

Saeedi, M. and Hashemi, M. and Mahdavi, M. and Rafinejad, A. and Najafi, Z. and Mirfazli, S.S. and Mohammadian, R. and Karimpour-Razkenari, E. and Kabudanian Ardestani, S. and Safavi, M. and Akbarzadeh, T. (2020) Synthesis and Anticancer Activity of N-(di/trimethoxyaryl)-5-arylisoxazole-3-carboxamide. Polycyclic Aromatic Compounds, 40 (5). pp. 1568-1580.

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In this study, a new series of N-(di or trimethoxyaryl)-5-arylisoxazole-3-carboxamide derivatives were synthesized and evaluated against human breast cancer cell lines including MCF-7, MDA-MB-231, and T-47D. Among the synthesized compounds, 5-(m-tolyl)-N-(3,4,5-trimethoxyphenyl)isoxazole-3-carboxamide (8f) showed significant cytotoxicity against all three cell lines comparing with etoposide as the reference drug. Also, Annexin V-FITC/propidium iodide and acridine orange/ethidium bromide staining assay were performed to validate apoptotic activity of compound 8f. The results confirmed induction of apoptosis at early stage. © 2019 Taylor & Francis Group, LLC.

Item Type: Article
Additional Information: cited By 1
Subjects: QZ Pathology
Depositing User: eprints admin
Date Deposited: 26 Jun 2021 03:54
Last Modified: 26 Jun 2021 03:54

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