Determine the most common clinical symptoms in COVID-19 patients: A systematic review and meta-analysis

Alimohamadi, Y. and Sepandi, M. and Taghdir, M. and Hosamirudsari, H. (2020) Determine the most common clinical symptoms in COVID-19 patients: A systematic review and meta-analysis. Journal of Preventive Medicine and Hygiene, 61 (3). E304-E312.

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Introduction. COVID-19 is an emerging infectious disease. The study about features of this infection could be very helpful in better knowledge about this infectious disease. The current systematic review and meta-analysis were aimed to estimate the prevalence of clinical symptoms of COVID-19 in a systematic review and meta-analysis. Methods. A systematic review using Medline/PubMed, Scopus, and Google scholar has been conducted. In the current systematic review and meta-analysis, the articles published in the period January 1, 2020, to April 2, 2020, written in English and reporting clinical symptoms of COVID-19 was reviewed. To assess, the presence of heterogeneity, the Cochran�s Q statistic, the I2 index, and the tau-squared test were used. Because of significant heterogeneity between the studies the random-effects model with 95 CI was used to calculate the pooled estimation of each symptom prevalence. Results. The most common symptoms in COVID-19 patients include: Fever 81.2 (95 CI: 77.9-84.4); Cough: 58.5 (95 CI: 54.2-62.8); Fatigue 38.5 (95 CI: 30.6-45.3); Dyspnea: 26.1 (95 CI: 20.4-31.8); and the Sputum: 25.8 (95 CI: 21.1-30.4). Based on the meta-regression results, the sample size used in different studies did not have a significant effect on the final estimate value (P > 0.05). Conclusions. Considering the main symptoms of COVID-19 such as Fever, Cough, Fatigue, and Dyspnea can have a key role in early detection of this disease and prevent the transmission of the disease to other people. © Copyright by Pacini Editore Srl, Pisa, Italy.

Item Type: Article
Additional Information: cited By 0
Uncontrolled Keywords: chest tightness; clinical feature; coronavirus disease 2019; coughing; diarrhea; dyspnea; fatigue; fever; headache; hemoptysis; human; myalgia; Review; sore throat; sputum; systematic review; thorax pain; Betacoronavirus; Coronavirus infection; differential diagnosis; meta analysis; pandemic; virology; virus pneumonia, Betacoronavirus; Coronavirus Infections; Cough; Diagnosis, Differential; Dyspnea; Fatigue; Fever; Humans; Pandemics; Pneumonia, Viral; Sputum
Subjects: WC Communicable Diseases
Depositing User: eprints admin
Date Deposited: 22 Jun 2021 03:39
Last Modified: 22 Jun 2021 03:39

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