Effect of drug-coated balloons versus bare-metal stents on endothelial function in patients with severe lower limb peripheral artery disease

Shafe, O. and Moosavi, J. and Shishehbor, M.H. and Sedigh, H. and Bakhshandeh, H. and Mahboubian, F. and Alilou, S. and Rafatnia, S. and Sadeghipour, P. (2020) Effect of drug-coated balloons versus bare-metal stents on endothelial function in patients with severe lower limb peripheral artery disease. Vascular, 28 (5). pp. 548-556.

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Background: Research shows impaired endothelial function in patients with vascular diseases and improved endothelial function following revascularization and medical treatment. There is, however, a dearth of data on the effects of different endovascular therapeutic strategies on endothelial function. We sought to compare the effects of two endovascular strategies of drug-coated balloons versus stenting on endothelial function. Methods: The reactive hyperemia index, the ankle-brachial index, and the toe-brachial index were measured in patients undergoing endovascular revascularization preprocedurally and on the 90th postprocedural day. After adjusting for baseline line characteristics, reactive hyperemia index were compared between the two groups at baseline and at 90 days. Results: Between January 2018 and March 2019, 86 patients were prospectively included in a non-randomized manner. Drug-coated ballooning alone was carried out on 46 patients, and bailout stenting after plain balloon angioplasty was performed on the remaining 40 patients The post-revascularization reactive hyperemia index exhibited a significant rise in both groups (1.58 ± 0.21 vs. 1.43 ± 0.20; P = 0.0001). There was no difference in the postprocedural reactive hyperemia index between the two treatment groups. Additionally, the follow-up reactive hyperemia index showed no significant change compared with the postprocedural reactive hyperemia index (1.58 ± 0.23 vs. 1.57 ± 0.22). The results of subgroup analysis between a group of clinically high-risk patients and a group of patients with complex lesions were similar to the aforementioned results. Conclusions: The reactive hyperemia index was significantly improved by endovascular therapy in our study population. However, no difference was observed between drug-coated ballooning and bare-metal stenting, which highlights the effects of vessel patency on endothelial function. © The Author(s) 2020.

Item Type: Article
Additional Information: cited By 0
Uncontrolled Keywords: adult; angioplasty; ankle brachial index; Article; cardiovascular parameters; chronic kidney failure; claudication; comparative study; controlled study; endothelium; endovascular surgery; follow up; high risk patient; human; lower limb; major clinical study; male; peripheral occlusive artery disease; priority journal; prospective study; reactive hyperemia index; revascularization; toe brachial index; adverse event; aged; comparative study; devices; female; hyperemia; intermittent claudication; lower limb; middle aged; pathophysiology; percutaneous transluminal angioplasty; peripheral occlusive artery disease; prosthesis design; risk factor; severity of illness index; stent; time factor; treatment outcome; vascular endothelium; vascular patency; vascularization; vasodilatation, biocompatible coated material; metal, Aged; Angioplasty, Balloon; Ankle Brachial Index; Coated Materials, Biocompatible; Endothelium, Vascular; Female; Humans; Hyperemia; Intermittent Claudication; Lower Extremity; Male; Metals; Middle Aged; Peripheral Arterial Disease; Prospective Studies; Prosthesis Design; Risk Factors; Severity of Illness Index; Stents; Time Factors; Treatment Outcome; Vascular Patency; Vasodilation
Subjects: WG Cardiovascular System
Depositing User: eprints admin
Date Deposited: 19 Jun 2021 05:59
Last Modified: 19 Jun 2021 05:59
URI: http://eprints.iums.ac.ir/id/eprint/33897

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