Mollazadeh, M. and Mohammadi-Khanaposhtani, M. and Azizian, H. and Zonouzi, A. and Abdolahi, Z. and Nadri, H. and Larijani, B. and Biglar, M. and Mahdavi, M. (2020) Design and synthesis of 2,4-dioxochroman-pyridinium-phenylacetamide derivatives as new anti-Alzheimer agents: in vitro and in silico studies. Journal of the Chinese Chemical Society, 67 (10). pp. 1910-1928.
Full text not available from this repository.Abstract
2,4-Dioxochroman-pyridinium-phenylacetamide derivatives 7a�n were synthesized and evaluated for their in vitro cholinesterase (ChE) inhibitory activities against acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE). Obtained results demonstrated that, among the synthesized compounds, two compounds, 7j and 7k, were more potent than the standard drug donepezil against BuChE and did not show cytotoxicity and carcinogenicity. Furthermore, through molecular modeling and molecular dynamic studies. we showed that these compounds can be located deep in the gorge cavity of BuChE and that they interacted with catalytic residues, acyl, and cholin-binding pockets of this enzyme. Support information. © 2020 The Chemical Society Located in Taipei & Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
| Item Type: | Article |
|---|---|
| Additional Information: | cited By 0 |
| Subjects: | WL Nervous System |
| Depositing User: | eprints admin |
| Date Deposited: | 16 Jun 2021 03:47 |
| Last Modified: | 16 Jun 2021 03:47 |
| URI: | http://eprints.iums.ac.ir/id/eprint/33991 |
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