Quantifying cortical bone free water using short echo time (STE-MRI) at 1.5 T

Abbasi-Rad, S. and Akbari, A. and Malekzadeh, M. and Shahgholi, M. and Arabalibeik, H. and Saligheh Rad, H. (2020) Quantifying cortical bone free water using short echo time (STE-MRI) at 1.5 T. Magnetic Resonance Imaging, 71. pp. 17-24.

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Purpose: The purpose of our study was to use Dual-TR STE-MR protocol as a clinical tool for cortical bone free water quantification at 1.5 T and validate it by comparing the obtained results (MR-derived results) with dehydration results. Methods: Human studies were compliant with HIPPA and were approved by the institutional review board. Short Echo Time (STE) MR imaging with different Repetition Times (TRs) was used for quantification of cortical bone free water T1 (T1free) and concentration (�free). The proposed strategy was compared with the dehydration technique in seven bovine cortical bone samples. The agreement between the two methods was quantified by using Bland and Altman analysis. Then we applied the technique on a cross-sectional population of thirty healthy volunteers (18F/12M) and examined the association of the biomarkers with age. Results: The mean values of �free for bovine cortical bone specimens were quantified as 4.37 and 5.34 by using STE-MR and dehydration techniques, respectively. The Bland and Altman analysis showed good agreement between the two methods along with the suggestion of 0.99 bias between them. Strong correlations were also reported between �free (r2 = 0.62) and T1free and age (r2 = 0.8). The reproducibility of the method, evaluated in eight subjects, yielded an intra-class correlation of 0.95. Conclusion: STE-MR imaging with dual-TR strategy is a clinical solution for quantifying cortical bone �free and T1free. © 2020 Elsevier Inc.

Item Type: Article
Additional Information: cited By 1
Uncontrolled Keywords: biological marker; cortical bone free water; unclassified drug; water, adult; age; aged; Article; bovine; concentration (parameter); controlled study; correlation coefficient; cortical bone; cross-sectional study; human; human experiment; nonhuman; normal human; nuclear magnetic resonance imaging; priority journal; quantitative analysis; reproducibility; short echo time magnetic resonance imaging
Subjects: WL Nervous System
WN Radiology. Diagnostic Imaging
WE Musculoskeletal System
Depositing User: eprints admin
Date Deposited: 08 Jun 2021 07:45
Last Modified: 08 Jun 2021 07:45
URI: http://eprints.iums.ac.ir/id/eprint/34141

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