Ashrafizadeh, M. and Zarrabi, A. and Hushmandi, K. and Zarrin, V. and Moghadam, E.R. and Zabolian, A. and Tavakol, S. and Samarghandian, S. and Najafi, M. (2020) PD-1/PD-L1 axis regulation in cancer therapy: The role of long non-coding RNAs and microRNAs. Life Sciences, 256.
Full text not available from this repository.Abstract
Cancer immunotherapy is a growing field nowadays. Among different molecular pathways, PD-1/PD-L1 signaling pathway plays a significant role in the regulation of immune responses. It has been reported that stimulation of PD-1/PD-L1 axis is correlated with T cell exhaustion, T cell apoptosis, and their reduced capability in proliferation. PD-1/PD-L1 axis provides a condition for immune evasion of cancer cells and interferes with anti-tumor immunity. Much attention has been directed towards targeting PD-1/PD-L1 axis in cancer immunotherapy. It seems that identification of upstream modulators of this axis can broaden our understanding to develop novel anti-tumor drugs for cancer immunotherapy. MicroRNAs (miRs) and long non-coding RNAs (lncRNAs) are key subcategories of non-coding RNAs, since they can regulate various biological processes by targeting different molecular pathways. In this review, we demonstrate that onco-suppressor miRs and lncRNAs inhibit PD-1/PD-L1 axis to provide anti-tumor immunity and in this way, other molecular pathways such as STAT, ZEB, PI3K/Akt and so on may be targeted. In contrast, oncogene miRs and lncRNAs induce PD-1/PD-L1 axis. Identification of miR/PD-1 and lncRNA/PD-1 signaling pathways can help us in finding an effective drug for cancer immunotherapy, and can direct us towards genetic manipulation of the aforementioned pathways. © 2020
| Item Type: | Article |
|---|---|
| Additional Information: | cited By 2 |
| Uncontrolled Keywords: | antineoplastic monoclonal antibody; long untranslated RNA; microRNA; programmed death 1 ligand 1; programmed death 1 receptor; regulator protein; STAT protein; unclassified drug; ZEB protein; long untranslated RNA; microRNA; programmed death 1 ligand 1; programmed death 1 receptor, apoptosis; autophagy (cellular); cancer cell; cancer immunotherapy; carcinogenesis; disease association; drug targeting; gene function; genetic association; human; immune evasion; lymphocyte function; lymphocyte proliferation; malignant neoplasm; nonhuman; oncogene; Pi3K/Akt signaling; protein function; regulatory mechanism; Review; signal transduction; T lymphocyte; treatment outcome; tumor immunity; tumor suppressor gene; animal; genetics; metabolism; neoplasm; signal transduction, Animals; B7-H1 Antigen; Humans; MicroRNAs; Neoplasms; Programmed Cell Death 1 Receptor; RNA, Long Noncoding; Signal Transduction |
| Subjects: | QZ Pathology |
| Depositing User: | eprints admin |
| Date Deposited: | 26 May 2021 08:57 |
| Last Modified: | 26 May 2021 08:57 |
| URI: | http://eprints.iums.ac.ir/id/eprint/34217 |
Actions (login required)
 |
View Item |
