Samimi, M. and Kashi, M. and Foroozanfard, F. and Karamali, M. and Bahmani, F. and Asemi, Z. and Hamidian, Y. and Talari, H.R. and Esmaillzadeh, A. (2016) The effects of vitamin D plus calcium supplementation on metabolic profiles, biomarkers of inflammation, oxidative stress and pregnancy outcomes in pregnant women at risk for pre-eclampsia. Journal of Human Nutrition and Dietetics, 29 (4). pp. 505-515.
Full text not available from this repository.Abstract
Background: The present study was designed to examine the effects of vitamin D plus calcium administration on metabolic profiles and pregnancy outcomes among women at risk for pre-eclampsia. Methods: In a prospective, double-blind, placebo-controlled trial, 60 women at risk for pre-eclampsia were randomised to take either 50 000 IU vitamin D3 every 2 weeks plus 1000 mg day�1 calcium supplements (as calcium carbonate) (n = 30) or to receive placebos at the same times (n = 30) from 20 to 32 weeks of gestation. Fasting blood samples were taken at baseline and 12 weeks after intervention to determine related variables. Newborn anthropometric measurements were determined. Results: Taking combined cholecalciferol and calcium supplements, compared to placebo, led to significant reductions in fasting plasma glucose (FPG) mean (SD) �5.7 (5.5) versus �0.6 (12.6) mg dL�1, P = 0.04, serum insulin concentrations �2.8 (6.0) versus +7.7 (9.8) μIU mL�1, P < 0.001, homeostasis model of assessment-insulin resistance �0.8 (1.3) versus +1.6 (2.2), P < 0.001, homeostatic model assessment-beta cell function �8.2 (25.8) versus +32.6 (41.3, P < 0.001 and a significant rise in quantitative insulin sensitivity check index score +0.02 (0.02) versus �0.02 (0.02, P < 0.001. Additionally, pregnant women who received cholecalciferol plus calcium supplements had increased serum high-density lipoprotein (HDL)-cholesterol +4.6 (8.3) versus �2.9 (7.7) mg dL�1, P = 0.001 and plasma total glutathione (GSH) concentrations +23.4 (124.0) versus �94.8 (130.2) μm, P = 0.001 compared to placebo. However, after adjustment for the baseline levels, maternal age and baseline body mass index, the effects on FPG levels (P = 0.13) and systolic blood pressure (P = 0.13) disappeared. Conclusions: Vitamin D plus calcium administration for 12 weeks had beneficial effects on glycaemic status, HDL-cholesterol, GSH and blood pressure among women at risk for pre-eclampsia. © 2015 The British Dietetic Association Ltd.
| Item Type: | Article |
|---|---|
| Additional Information: | cited By 8 |
| Depositing User: | eprints admin |
| Date Deposited: | 07 Jul 2018 04:20 |
| Last Modified: | 07 Jul 2018 04:20 |
| URI: | http://eprints.iums.ac.ir/id/eprint/3424 |
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