First report of human parvovirus 4 detection in Iran

Asiyabi, S. and Nejati, A. and Shoja, Z. and Shahmahmoodi, S. and Jalilvand, S. and Farahmand, M. and Gorzin, A.-A. and Najafi, A. and Haji Mollahoseini, M. and Marashi, S.M. (2016) First report of human parvovirus 4 detection in Iran. Journal of Medical Virology, 88 (8). pp. 1314-1318.

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Parvovirus 4 (PARV4) is an emerging and intriguing virus that currently received many attentions. High prevalence of PARV4 infection in high-risk groups such as HIV infected patients highlights the potential clinical outcomes that this virus might have. Molecular techniques were used to determine both the presence and the genotype of circulating PARV4 on previously collected serum samples from 133 HIV infected patients and 120 healthy blood donors. Nested PCR was applied to assess the presence of PARV4 DNA genome in both groups. PARV4 DNA was detected in 35.3 of HIV infected patients compared to 16.6 healthy donors. To genetically characterize the PARV4 genotype in these groups, positive samples were randomly selected and subjected for sequencing and phylogenetic analysis. All PARV4 sequences were found to be genotype 1 and clustered with the reference sequences of PARV4 genotype 1. © 2016 Wiley Periodicals, Inc.

Item Type: Article
Additional Information: cited By 2
Depositing User: eprints admin
Date Deposited: 07 Jul 2018 04:18
Last Modified: 07 Jul 2018 04:18

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