Ostadhadi, S. and Ahangari, M. and Nikoui, V. and Norouzi-Javidan, A. and Zolfaghari, S. and Jazaeri, F. and Chamanara, M. and Akbarian, R. and Dehpour, A.-R. (2016) Pharmacological evidence for the involvement of the NMDA receptor and nitric oxide pathway in the antidepressant-like effect of lamotrigine in the mouse forced swimming test. Biomedicine and Pharmacotherapy, 82. pp. 713-721.
Full text not available from this repository.Abstract
Lamotrigine is an anticonvulsant agent that shows clinical antidepressant properties. The aim of the present study was to investigate the involvement of N-methyl- d-aspartate (NMDA) receptors and nitric oxide-cyclic guanosine monophosphate (NO-cGMP) synthesis in possible antidepressant-like effect of lamotrigine in forced swimming test (FST) in mice. Intraperitoneal administration of lamotrigine (10 mg/kg) decreased the immobility time in the FST (P < 0.01) without any effect on locomotor activity in the open-field test (OFT), while higher dose of lamotrigine (30 mg/kg) reduced the immobility time in the FST (P < 0.001) as well as the number of crossings in the OFT. Pretreatment of animals with NMDA (75 mg/kg), l-arginine (750 mg/kg, a substrate for nitric oxide synthase NOS) or sildenafil (5 mg/kg, a phosphodiesterase PDE 5 inhibitor) reversed the antidepressant-like effect of lamotrigine (10 mg/kg) in the FST. Injection of l-nitroarginine methyl ester (l-NAME, 10 mg/kg, a non-specific NOS inhibitor), 7-nitroindazole (30 mg/kg, a neuronal NOS inhibitor), methylene blue (20 mg/kg, an inhibitor of both NOS and soluble guanylate cyclase sGC), or MK-801 (0.05 mg/kg), ketamine (1 mg/kg), and magnesium sulfate (10 mg/kg) as NMDA receptor antagonists in combination with a sub-effective dose of lamotrigine (5 mg/kg) diminished the immobility time of animals in the FST compared with either drug alone. None of the drugs produced significant effects on the locomotor activity in the OFT. Based on our findings, it is suggested that the antidepressant-like effect of lamotrigine might mediated through inhibition of either NMDA receptors or NO-cGMP synthesis. © 2016 .
| Item Type: | Article |
|---|---|
| Additional Information: | cited By 13 |
| Depositing User: | eprints admin |
| Date Deposited: | 07 Jul 2018 04:18 |
| Last Modified: | 07 Jul 2018 04:18 |
| URI: | http://eprints.iums.ac.ir/id/eprint/3435 |
Actions (login required)
 |
View Item |
