Yousefifard, M. and Rahimi-Movaghar, V. and Nasirinezhad, F. and Baikpour, M. and Safari, S. and Saadat, S. and Moghadas Jafari, A. and Asady, H. and Razavi Tousi, S.M.T. and Hosseini, M. (2016) Neural stem/progenitor cell transplantation for spinal cord injury treatment; A systematic review and meta-analysis. Neuroscience, 322. pp. 377-397.
Full text not available from this repository.Abstract
Despite the vast improvements of cell therapy in spinal cord injury treatment, no optimum protocol has been developed for application of neural stem/progenitor cells. In this regard, the present meta-analysis showed that the efficacy of the neural stem/progenitor cell (NSPC) transplantation depends mainly on injury model, intervention phase, transplanted cell count, immunosuppressive use, and probably stem cell source. Improved functional recovery post NSPC transplantation was found to be higher in transection and contusion models. Moreover, NSPC transplantation in acute phase of spinal injury was found to have better functional recovery. Higher doses (>3 � 106 cell/kg) were also shown to be optimum for transplantation, but immunosuppressive agent administration negatively affected the motor function recovery. Scaffold use in NSPC transplantation could also effectively raise functional recovery. © 2016.
| Item Type: | Article |
|---|---|
| Additional Information: | cited By 24 |
| Depositing User: | eprints admin |
| Date Deposited: | 04 Jul 2018 09:49 |
| Last Modified: | 04 Jul 2018 09:49 |
| URI: | http://eprints.iums.ac.ir/id/eprint/3649 |
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