Behboudi-Gandevani, S. and Ramezani Tehrani, F. and Rostami Dovom, M. and Farahmand, M. and Bahri Khomami, M. and Noroozzadeh, M. and Kabir, A. and Azizi, F. (2016) Insulin resistance in obesity and polycystic ovary syndrome: Systematic review and meta-analysis of observational studies. Gynecological Endocrinology, 32 (5). pp. 343-353.
Full text not available from this repository.Abstract
We aimed at investigating whether insulin resistance (IR)/sensitivity are impaired in obese/non-obese polycystic ovary syndrome (PCOS) and obese/non-obese healthy controls. A comprehensive literature search was performed for observational, English language studies. Meta-analysis was performed with the random effects model according to the heterogeneity. Eligible studies, involving 3037 women in four groups of: 1-obese, PCOS; 2-non-obese, PCOS, 3-obese, non-PCOS and 4-Non-obese, non-PCOS were included. Based on the insulin resistance index (HOMA-IR) analysis, the pooled mean (95 Conf. Interval) of HOMA IR in groups 1-4 were 4.38 (3.84, 4.92), 2.68 (2.16, 3.20), 2.44 (2.06, 2.82) and 1.34 (1.06, 1.63), respectively. Meta-analysis showed that group 1 (obese, PCOS patients) statistically have the highest IR and group 4 (non-obese, non-PCOS women) have the highest insulin sensitivity. Group 2 (non-obese, PCOS patients) and group 3 (obese, non-PCOS women) were between this range and they had lower IR than group 1 (obese, PCOS) and lower insulin sensitivity than group 4 (non-obese, non-PCOS). So, there were statistical differences between all groups except between groups 2 and 3. Insulin sensitivity indexes (quickie and ISI), also confirm the IR index (HOMA-IR) results. Based on different IR/sensitivity indexes, we found no evidence of any different effects of BMI � 30 kg/m2 on IR/sensitivity. In conclusion, PCOS status intensifies the adverse effects of obesity on IR, it has to be appropriately addressed in primary and secondary preventive cares and treatments provided for these women. © 2015 Taylor & Francis.
| Item Type: | Article |
|---|---|
| Additional Information: | cited By 16 |
| Depositing User: | eprints admin |
| Date Deposited: | 04 Jul 2018 09:50 |
| Last Modified: | 04 Jul 2018 09:50 |
| URI: | http://eprints.iums.ac.ir/id/eprint/3655 |
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