Rakhshan, K. and Azizi, Y. and Naderi, N. and Ghardashi Afousi, A. and Aboutaleb, N. (2018) ELABELA (ELA) Peptide Exerts Cardioprotection Against Myocardial Infarction by Targeting Oxidative Stress and the Improvement of Heart Function. International Journal of Peptide Research and Therapeutics. pp. 1-9.
Full text not available from this repository.Abstract
Emerging evidence has shown that ELA peptide plays a pivotal role in cardiac development and modulation of vascular and cardiac function. In the current work, we sought to examine the possible therapeutic potential of ELA peptide to reduce I/R injury following MI and elucidate the possible mechanisms by which ELA peptide may ameliorate injury and improve heart function after MI. 5 µg/kg of ELA peptide was administrated intraperitoneally in rats once per day for 4 days after ischemia of heart for 30 min. Male Wistar rats were sacrificed at 24 h and 2 weeks after reperfusion. The infarct size was determined by TTC staining 2 weeks after reperfusion. ELISA was employed to measure serum level of myocardial injury markers such as LDH, CK-MB and Troponin I and oxidative stress markers such as membrane lipid peroxidation (MDA), GSH and SOD activities in the first 24 h. Cardiac function was evaluated using echocardiography prior to MI and 2 weeks after reperfusion. After administration of ELA peptide in MI rats, infarct size, serum levels of LDH, CK-MB, Troponin I and tissue levels of MDA were significantly reduced; GSH and SOD activities were markedly increased (p < 0.05). Likewise, ELA peptide improved cardiac function 2 weeks after MI (p < 0.05). ELA peptide administration for 4 days after MI could reduce injury by targeting oxidative stress and improvement of cardiac function. These findings establish a fundamental foundation for future peptide research and therapy. © 2018 Springer Science+Business Media, LLC, part of Springer Nature
| Item Type: | Article |
|---|---|
| Additional Information: | cited By 0; Article in Press |
| Depositing User: | eprints admin |
| Date Deposited: | 05 Aug 2018 05:33 |
| Last Modified: | 05 Aug 2018 05:33 |
| URI: | http://eprints.iums.ac.ir/id/eprint/373 |
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