Emami Nejad, A. and Najafgholian, S. and Rostami, A. and Sistani, A. and Shojaeifar, S. and Esparvarinha, M. and Nedaeinia, R. and Haghjooy Javanmard, S. and Taherian, M. and Ahmadlou, M. and Salehi, R. and Sadeghi, B. and Manian, M. (2021) The role of hypoxia in the tumor microenvironment and development of cancer stem cell: a novel approach to developing treatment. Cancer Cell International, 21 (1).
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The role of hypoxia in the tumor microenvironment and development of cancer stem cell a novel approach to developing treatment.pdf Download (4MB) | Preview |
Abstract
Hypoxia is a common feature of solid tumors, and develops because of the rapid growth of the tumor that outstrips the oxygen supply, and impaired blood flow due to the formation of abnormal blood vessels supplying the tumor. It has been reported that tumor hypoxia can: activate angiogenesis, thereby enhancing invasiveness and risk of metastasis; increase survival of tumor, as well as suppress anti-tumor immunity and hamper the therapeutic response. Hypoxia mediates these effects by several potential mechanisms: altering gene expression, the activation of oncogenes, inactivation of suppressor genes, reducing genomic stability and clonal selection. We have reviewed the effects of hypoxia on tumor biology and the possible strategiesto manage the hypoxic tumor microenvironment (TME), highlighting the potential use of cancer stem cells in tumor treatment. © 2021, The Author(s).
| Item Type: | Article |
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| Additional Information: | cited By 11 |
| Uncontrolled Keywords: | angiogenic factor; hypoxia inducible factor; immunological antineoplastic agent; microRNA; transcription factor, adaptation; angiogenesis; cancer chemotherapy; cancer growth; cancer radiotherapy; cancer resistance; cancer stem cell; cancer therapy; carcinogenesis; disease course; down regulation; epithelial mesenchymal transition; exosome; human; immunosuppressive treatment; malignant neoplasm; metastasis; nonhuman; protein expression; protein targeting; Review; signal transduction; tumor hypoxia; tumor microenvironment; upregulation |
| Subjects: | QU Biochemistry. Cell Biology and Genetics QZ Pathology |
| Depositing User: | eprints admin |
| Date Deposited: | 25 Aug 2021 06:11 |
| Last Modified: | 25 Aug 2021 06:11 |
| URI: | http://eprints.iums.ac.ir/id/eprint/38970 |
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