Akbari, A. and Sedaghat, M. and Heshmati, J. and Tabaeian, S.P. and Dehghani, S. and Pizarro, A.B. and Rostami, Z. and Agah, S. (2021) Molecular mechanisms underlying curcumin-mediated microRNA regulation in carcinogenesis; Focused on gastrointestinal cancers. Biomedicine and Pharmacotherapy, 141.
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Molecular mechanisms underlying curcumin-mediated microRNA regulation in carcinogenesis; Focused on gastrointestinal cancers.pdf Download (1MB) | Preview |
Abstract
Curcumin is a bioactive ingredient found in the Rhizomes of Curcuma longa. Curcumin is well known for its chemopreventive and anti-cancer properties. Recent findings have demonstrated several pharmacological and biological impacts of curcumin, related to the control and the management of gastrointestinal cancers. Mechanistically, curcumin exerts its biological impacts via antioxidant and anti-inflammatory effects through the interaction with various transcription factors and signaling molecules. Moreover, epigenetic modulators such as microRNAs (miRNAs) have been revealed as novel targets of curcumin. Curcumin was discovered to regulate the expression of numerous pathogenic miRNAs in gastric, colorectal, esophageal and liver cancers. The present systematic review was performed to identify miRNAs that are modulated by curcumin in gastrointestinal cancers. © 2021
| Item Type: | Article |
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| Additional Information: | cited By 0 |
| Subjects: | WI Digestive System QZ Pathology |
| Depositing User: | eprints admin |
| Date Deposited: | 31 Aug 2021 06:05 |
| Last Modified: | 31 Aug 2021 06:05 |
| URI: | http://eprints.iums.ac.ir/id/eprint/39029 |
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