Shi, Z. and Mahdavian, Y. and Mahdavian, Y. and Mahdigholizad, S. and Irani, P. and Karimian, M. and Abbasi, N. and Ghaneialvar, H. and Zangeneh, A. and Mahdi Zangeneh, M. (2021) Cu immobilized on chitosan-modified iron oxide magnetic nanoparticles: Preparation, characterization and investigation of its anti-lung cancer effects. Arabian Journal of Chemistry, 14 (8).
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Cu immobilized on chitosan-modified iron oxide magnetic nanoparticles Preparation, characterization and investigation of its anti-lung cancer effects.pdf Download (2MB) | Preview |
Abstract
Chitosan is a linear polysaccharide and non-toxic bioactive polymer with a wide variety of applications due to its functional properties such as ease of modification, and biodegradability. In this study, a green protocol for supporting of Cu(II) on chitosan-encapsulated magnetic Fe3O4 nanoparticles is described. The morphological and physicochemical features of the material were determined using several advanced techniques like fourier transformed infrared spectroscopy (FT-IR), field emission scanning electron microscopy (FESEM), transmission electron microscopy (TEM), energy dispersive X-ray spectroscopy (EDS), X-ray diffraction (XRD), inductively coupled plasma (ICP), vibrating sample magnetometer (VSM) and X-ray photoelectron spectroscopy (XPS). The average diameter of the NPs was approximately 15�25 nm. In addition, the Fe3O/CS/Cu(II) nanocomposite was engaged in biological assays like study of anti-oxidant properties by DPPH mediated free radical scavenging test using BHT as a reference molecule. Thereafter, on having a significant IC50 value in radical scavenging assay, we extended the bio-application of the desired nanocomposite in anticancer study of lung well-differentiated bronchogenic adenocarcinoma, lung moderately differentiated adenocarcinoma, and lung poorly differentiated adenocarcinoma of human lung in-vitro conditions. In the cytotoxicity and anti-human lung studies, the nanocomposite was treated to lung cancer lung well-differentiated bronchogenic adenocarcinoma (HLC-1), lung moderately differentiated adenocarcinoma (LC-2/ad), and lung poorly differentiated adenocarcinoma (PC-14) cell line following MTT assay. The cell viability of malignant lung cell line reduced dose-dependently in the presence of Fe3O/CS/Cu(II) nanocomposite. The recent results suggest that Fe3O/CS/Cu(II) nanocomposite have a suitable anticancer activity against lung cell lines. © 2021
| Item Type: | Article |
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| Additional Information: | cited By 0 |
| Uncontrolled Keywords: | Biodegradability; Biological organs; Cell culture; Cells; Chitosan; Copper compounds; Diseases; Energy dispersive spectroscopy; Field emission microscopes; Free radicals; High resolution transmission electron microscopy; Inductively coupled plasma; Infrared spectroscopy; Magnetite; Nanocomposites; Nanomagnetics; Scanning electron microscopy; X ray photoelectron spectroscopy, Antioxidant assays; Bioactive polymers; Cell lines; Fe+3+; Human lung; Lung Cancer; Lung cells; Magnetic nanocomposites; Nanoparticle preparations; Non-toxic, Copper |
| Subjects: | QT Physiology |
| Depositing User: | eprints admin |
| Date Deposited: | 04 Sep 2021 07:08 |
| Last Modified: | 04 Sep 2021 07:08 |
| URI: | http://eprints.iums.ac.ir/id/eprint/39070 |
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