Mohammadi, E. and Shafiee, F. and Shahzamani, K. and Ranjbar, M.M. and Alibakhshi, A. and Ahangarzadeh, S. and Beikmohammadi, L. and Shariati, L. and Hooshmandi, S. and Ataei, B. and Javanmard, S.H. (2021) Novel and emerging mutations of SARS-CoV-2: Biomedical implications. Biomedicine and Pharmacotherapy, 139.
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Abstract
Coronavirus disease-19 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The SARS-CoV-2 virus strains has geographical diversity associated with diverse severity, mortality rate, and response to treatment that were characterized using phylogenetic network analysis of SARS-CoV-2 genomes. Although, there is no explicit and integrative explanation for these variations, the genetic arrangement, and stability of SARS-CoV-2 are basic contributing factors to its virulence and pathogenesis. Hence, understanding these features can be used to predict the future transmission dynamics of SARS-CoV-2 infection, drug development, and vaccine. In this review, we discuss the most recent findings on the mutations in the SARS-CoV-2, which provide valuable information on the genetic diversity of SARS-CoV-2, especially for DNA-based diagnosis, antivirals, and vaccine development for COVID-19. © 2021
| Item Type: | Article |
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| Additional Information: | cited By 0 |
| Uncontrolled Keywords: | coronavirus spike glycoprotein; spike protein, SARS-CoV-2, genetics; human; mutation; virus genome, COVID-19; Genome, Viral; Humans; Mutation; SARS-CoV-2; Spike Glycoprotein, Coronavirus |
| Subjects: | WA Public Health WC Communicable Diseases |
| Depositing User: | eprints admin |
| Date Deposited: | 27 Oct 2021 05:18 |
| Last Modified: | 27 Oct 2021 05:18 |
| URI: | http://eprints.iums.ac.ir/id/eprint/39142 |
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