Novel and emerging mutations of SARS-CoV-2: Biomedical implications

Mohammadi, E. and Shafiee, F. and Shahzamani, K. and Ranjbar, M.M. and Alibakhshi, A. and Ahangarzadeh, S. and Beikmohammadi, L. and Shariati, L. and Hooshmandi, S. and Ataei, B. and Javanmard, S.H. (2021) Novel and emerging mutations of SARS-CoV-2: Biomedical implications. Biomedicine and Pharmacotherapy, 139.

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Coronavirus disease-19 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The SARS-CoV-2 virus strains has geographical diversity associated with diverse severity, mortality rate, and response to treatment that were characterized using phylogenetic network analysis of SARS-CoV-2 genomes. Although, there is no explicit and integrative explanation for these variations, the genetic arrangement, and stability of SARS-CoV-2 are basic contributing factors to its virulence and pathogenesis. Hence, understanding these features can be used to predict the future transmission dynamics of SARS-CoV-2 infection, drug development, and vaccine. In this review, we discuss the most recent findings on the mutations in the SARS-CoV-2, which provide valuable information on the genetic diversity of SARS-CoV-2, especially for DNA-based diagnosis, antivirals, and vaccine development for COVID-19. © 2021

Item Type: Article
Additional Information: cited By 0
Uncontrolled Keywords: coronavirus spike glycoprotein; spike protein, SARS-CoV-2, genetics; human; mutation; virus genome, COVID-19; Genome, Viral; Humans; Mutation; SARS-CoV-2; Spike Glycoprotein, Coronavirus
Subjects: WA Public Health
WC Communicable Diseases
Depositing User: eprints admin
Date Deposited: 27 Oct 2021 05:18
Last Modified: 27 Oct 2021 05:18

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