Tajadod, S. and Jazayeri, S. and Aryaeian, N. and Tehrani-Doost, M. and Hosseini, F. and Khosravi-Darani, K. and Effatpanah, M. and Moradi, N. and Fallah, S. and Khajehpour, Z. and Elahinejad, V. (2021) The effect of probiotics on cardiovascular risk factors in patients with major depressive disorder: A randomized clinical trial study. Journal of Isfahan Medical School, 39 (618). pp. 189-197.
Full text not available from this repository.Abstract
Background: Depression has been associated with cardiovascular disease in previous research. They also have stated that probiotics have a protective effect against cardiovascular disease. The aim of this study was to investigate the role of probiotics in this association. Methods: In this study, fifty patients with major depressive disorder (MDD) who were candidates for fluoxetine were randomly selected and divided into two groups. One group received fluoxetine (20 mg) with a probiotic supplement which contained Lactobacillus holoticus and Bifidobacterium langum (2 � 109 CFU/g for each) and another group received fluoxetine with a placebo during 8-week period. 10 ml of fasting blood was taken from patients for biochemical measurements. Findings: After 8 weeks of intervention, patients in the probiotic group had significant decrease in serum high-sensitivity C-reactive protein (hs-CRP) levels compared with the placebo group (2.599± 0.990 vs. 2.704 ± 1.361 ng/ml, P = 0.017). At the end of the study, although, there was significant increase in catalase (30.06 ± 3.443 vs. 26.24 ± 6.908 U, P = 0.037) and decrease in malondialdehyde (MDA) (15.13 ± 3.574vs. 17.40 ± 3.170 mg/dl, P = 0.029) levels in the probiotic group, but after 8 weeks, there was no significant difference between the two groups. Other variables did not change significantly. Conclusion: Although probiotics can improve cardiovascular status by reducing general inflammation in the body, they are not specifically associated with lower risk of cardiovascular diseases. © 2021 Isfahan University of Medical Sciences(IUMS). All rights reserved.
| Item Type: | Article |
|---|---|
| Additional Information: | cited By 0 |
| Subjects: | WM Psychiatry WG Cardiovascular System QV Pharmacology |
| Depositing User: | eprints admin |
| Date Deposited: | 28 Nov 2021 06:47 |
| Last Modified: | 28 Nov 2021 06:47 |
| URI: | http://eprints.iums.ac.ir/id/eprint/39224 |
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