Biagioni, A. and Tavakol, S. and Ahmadirad, N. and Zahmatkeshan, M. and Magnelli, L. and Mandegary, A. and Samareh Fekri, H. and Asadi, M.H. and Mohammadinejad, R. and Ahn, K.S. (2021) Small nucleolar RNA host genes promoting epithelial�mesenchymal transition lead cancer progression and metastasis. IUBMB Life, 73 (6). pp. 825-842.
Full text not available from this repository.Abstract
The small nucleolar RNA host genes (SNHGs) belong to the long non-coding RNAs and are reported to be able to influence all three levels of cellular information-bearing molecules, that is, DNA, RNA, and proteins, resulting in the generation of complex phenomena. As the host genes of the small nucleolar RNAs (snoRNAs), they are commonly localized in the nucleolus, where they exert multiple regulatory functions orchestrating cellular homeostasis and differentiation as well as metastasis and chemoresistance. Indeed, worldwide literature has reported their involvement in the epithelial�mesenchymal transition (EMT) of different histotypes of cancer, being able to exploit peculiar features, for example, the possibility to act both in the nucleus and the cytoplasm. Moreover, SNHGs regulation is a fundamental topic to better understand their role in tumor progression albeit such mechanism is still debated. Here, we reviewed the biological functions of SNHGs in particular in the EMT process and discussed the perspectives for new cancer therapies. © 2021 International Union of Biochemistry and Molecular Biology.
| Item Type: | Article |
|---|---|
| Additional Information: | cited By 0 |
| Subjects: | QU Biochemistry. Cell Biology and Genetics QZ Pathology |
| Depositing User: | eprints admin |
| Date Deposited: | 30 Nov 2021 05:36 |
| Last Modified: | 30 Nov 2021 05:36 |
| URI: | http://eprints.iums.ac.ir/id/eprint/39265 |
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