Mehdinezhad, N. and Aryaeian, N. and Vafa, M. and Saeedpour, A. and Ebrahimi, A. and Mobaderi, T. and Fahimi, R. and Sajadi Hezaveh, Z. (2021) Effect of spirulina and chlorella alone and combined on the healing process of diabetic wounds: an experimental model of diabetic rats. Journal of Diabetes and Metabolic Disorders, 20 (1). pp. 161-169.
Full text not available from this repository.Abstract
Background: Using chemical agents to cure diabetes mellitus and its complications may be accompanied by complications. New natural agents, such as spirulina and chlorella, could be used as alternative choices in this case. Methods: 65 male Wistar rats were allocated to 5 groups: A (healthy control), B (diabetic rats with a normal diet), C (diabetic rats supplemented with 50 g/kg/day spirulina), D (diabetic rats supplemented with 50 g/kg/day chlorella) and E (diabetic rats supplemented with 25 g/kg/day chlorella and 25 g/kg/day spirulina). After 21 days, wounds were inflicted on the back of rats. Assessment of blood sugar (BS), high-sensitivity C-reactive protein (hs-CRP), vascular endothelial growth factor (VEGF), granulation tissue formation, vascularization, epithelialization, and percentage of wound healing were determined along with macroscopic examinations. Results: The microscopic changes at days 3, 7, 14, and 21 showed significant evidence of improved angiogenesis, epithelial proliferation, and granulation tissue formation in the spirulina and chlorella treated rats compared with the controls (p�0.05). Both spirulina and chlorella treatments of diabetic rats resulted in a significant reduction in BS and weight (p�0.05), but VEGF and hs-CRP levels did not significantly change (p > 0.05). Percentage of wound healing was 100 on day 21 in all groups, except the control group B (97.8 ± 1.15). Conclusions: The results of this study showed that supplementation with spirulina and chlorella alone and combined could improve wound healing indices in diabetic rats and could therefore be recommended for the management of diabetic ulcer. © 2021, Springer Nature Switzerland AG.
| Item Type: | Article |
|---|---|
| Additional Information: | cited By 0 |
| Subjects: | QV Pharmacology |
| Depositing User: | eprints admin |
| Date Deposited: | 13 Dec 2021 06:59 |
| Last Modified: | 13 Dec 2021 06:59 |
| URI: | http://eprints.iums.ac.ir/id/eprint/39337 |
Actions (login required)
 |
View Item |
