Emami, M.R. and Jamshidi, S. and Zarezadeh, M. and Khorshidi, M. and Olang, B. and Sajadi Hezaveh, Z. and Sohouli, M. and Aryaeian, N. (2021) Can vitamin E supplementation affect obesity indices? A systematic review and meta-analysis of twenty-four randomized controlled trials. Clinical Nutrition, 40 (5). pp. 3201-3209.
Full text not available from this repository.Abstract
Background: Several mechanisms have been proposed for the effect of vitamin E on weight loss. Yet various interventional studies with wide ranges of doses and durations have reported contradictory results. Methods: Cochrane Library, PubMed, Scopus, and Embase databases were searched up to December 2020. Meta-analysis was performed using random-effect method. Effect size was presented as weighted mean difference (WMD) and 95 confidence interval (CI). Heterogeneity was evaluated using the I2 index. In order to identification of potential sources of heterogeneity, predefined subgroup and meta regression analyses was conducted. Results: A total of 24 studies with 33 data sets were included. There was no significant effect of vitamin E on weight (WMD: 0.15, 95 CI: �1.35 to 1.65, P = 0.847), body mass index (BMI) (WMD = 0.04, 95 CI: �0.29 to 0.37, P = 0.815), and waist circumference (WC) (WMD = �0.19 kg, 95 CI: �2.06 to 1.68, P = 0.842), respectively. However, subgroup analysis revealed that vitamin E supplementation in studies conducted on participants with normal BMI (18.5�24.9) had increasing impact on BMI (P = 0.047). Conclusion: There was no significant effect of vitamin E supplementation on weight, BMI and WC. However, vitamin E supplementation might be associated with increasing BMI in people with normal BMI (18.5�24.9). © 2021 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism
| Item Type: | Article |
|---|---|
| Additional Information: | cited By 0 |
| Uncontrolled Keywords: | alpha tocopherol, Article; body mass; body weight; human; meta analysis; obesity; randomized controlled trial (topic); systematic review; vitamin supplementation; waist circumference |
| Subjects: | QV Pharmacology |
| Depositing User: | eprints admin |
| Date Deposited: | 04 Jan 2022 06:54 |
| Last Modified: | 04 Jan 2022 06:54 |
| URI: | http://eprints.iums.ac.ir/id/eprint/39458 |
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