Regional vitamin C in Bier block reduces the incidence of CRPS-1 following distal radius fracture surgery

Alimian, M. and Sobhani Eraghi, A. and Chavoshizadeh, S.A. and Mohseni, M. and Mousavi, E. and Movassaghi, S. (2021) Regional vitamin C in Bier block reduces the incidence of CRPS-1 following distal radius fracture surgery. European Journal of Orthopaedic Surgery and Traumatology, 31 (4). pp. 689-693.

Full text not available from this repository.
Official URL:


Background: Systemic vitamin C supplementation after wrist fracture has been suggested to reduce the incidence of complex regional pain syndrome (CRPS). This study aimed to evaluate the effect of regional vitamin C in Bier block in the early phase of fracture on CRPS occurrence following surgery for distal radius fractures. Methods: Seventy-four patients with isolated extra-articular distal radius fracture with the plan of fixation under Bier block were enrolled. Patients were assigned randomly into two groups: receiving either 500 mg vitamin C or sterile water as a Bier block adjuvant. Both groups received 500 mg of oral vitamin C for six weeks. The patients were evaluated for CRPS signs and symptoms at 2, 4, 6, and 12 weeks post-surgery. Results: The overall incidence of CRPS 12 weeks after surgery in the vitamin C group was significantly less than the controls (22.9 vs 45.5, p = 0.04). Logistic regression analysis showed that the only significant contribution in predicting the incidence of CRPS came from the intervention variable (OR 0.26, CI95 0.08�0.85; P = 0.027). Conclusions: The findings suggest that adding vitamin C 500 mg to the local anesthetic in Bier block significantly reduces the incidence of CRPS following distal radius fractures. © 2020, Springer-Verlag France SAS, part of Springer Nature.

Item Type: Article
Additional Information: cited By 0
Uncontrolled Keywords: ascorbic acid; lidocaine; sterile water, adult; analgesia; Article; Bier block; complex regional pain syndrome type I; controlled study; distal radius fracture; double blind procedure; female; fracture fixation; human; incidence; intravenous regional anesthesia; major clinical study; male; middle aged; prediction; priority journal; randomized controlled trial; therapy effect; treatment duration
Subjects: WE Musculoskeletal System
QV Pharmacology
Depositing User: eprints admin
Date Deposited: 12 Jan 2022 07:05
Last Modified: 12 Jan 2022 07:05

Actions (login required)

View Item View Item