A systematic review and meta-analysis of human biomonitoring studies on exposure to environmental pollutants in Iran

Hadei, M. and Shahsavani, A. and Hopke, P.K. and Naseri, S. and Yazdanbakhsh, A. and Sadani, M. and Mesdaghinia, A. and Yarahmadi, M. and Rahmatinia, M. and Fallah, S. and Emam, B. and Kermani, M. and Jaafarzadeh, N. and Alipour, M. and Hassanzadeh, V. and Bazzazpour, S. and Nazari, S.S.H. (2021) A systematic review and meta-analysis of human biomonitoring studies on exposure to environmental pollutants in Iran. Ecotoxicology and Environmental Safety, 212.

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Abstract

Population exposure to environmental contaminants can be precisely observed through human biomonitoring studies. The present study aimed to systematically review all the biomonitoring studies conducted in Iran on some selected carcinogen environmental pollutants. In this systematic review study, 11 carcinogen agents were selected including arsenic, cadmium, chromium, nickel, lindane, benzene, trichloroethylene (TCE), pentachlorophenol (PCP), radon-222, radium-224, � 226, � 228, and tobacco smoke. The Web of Science, PubMed, and Scopus databases were searched for peer-reviewed articles published in English. After several screening steps, data were extracted from the studies. Meta-analyses (a random-effect model using the DerSimonian-Laired method) were performed only for the biomarkers with more than three eligible articles, including cadmium in blood and breast milk, and arsenic in breast milk. Methodological quality of the studies was assessed using the Newcastle-Ottawa Quality Assessment Scale adapted for cross-sectional studies. Of the 610 articles found in the database search, 30 studies were eligible for qualitative review, and 13 were included in the meta-analysis (cadmium in blood (n = 3), cadmium in breast milk (n = 6), and arsenic in breast milk (n = 4)). The overall pooled average concentrations (95 CI) of cadmium in blood, cadmium in breast milk, and arsenic in breast milk were 0.11 (95 CI: 0.08, 0.14), 5.38 (95 CI: 3.60, 6.96), and 1.42 (95 CI: 1.02, 1.81) µg/L, respectively. These values were compared with the biomarker concentrations in other countries and health-based guideline values. This study showed that there is a need for comprehensive action plans to reduce the exposure of general population to these environmental contaminants. © 2021

Item Type: Article
Additional Information: cited By 0
Uncontrolled Keywords: arsenic; benzene; cadmium; chromium; cotinine; drinking water; heavy metal; lindane; muconic acid; nickel; pentachlorophenol; radium 224; radium 226; radium 228; radon 222; tobacco smoke; trichloroethylene; arsenic; cadmium; chromium; nickel, bioaccumulation; biomarker; biomonitoring; carcinogen; concentration (composition); heavy metal; meta-analysis; qualitative analysis; smoking, atomic absorption spectrometry; biological monitoring; breast milk; cancer risk; environmental exposure; enzyme linked immunosorbent assay; exhaust gas; food contamination; gas chromatography; heavy metal blood level; human; inductively coupled plasma mass spectrometry; Iran; mass fragmentography; milk level; Newcastle-Ottawa scale; particulate matter 10; particulate matter 2.5; passive smoking; pollutant; population exposure; Review; systematic review; urine level; chemistry; cross-sectional study; environmental exposure; female; pollutant; pollution, Iran, Nicotiana tabacum; Scopus, Arsenic; Biological Monitoring; Cadmium; Chromium; Cross-Sectional Studies; Environmental Exposure; Environmental Pollutants; Environmental Pollution; Female; Humans; Iran; Milk, Human; Nickel
Subjects: WA Public Health
QV Pharmacology
Depositing User: eprints admin
Date Deposited: 02 Nov 2022 05:37
Last Modified: 02 Nov 2022 05:37
URI: http://eprints.iums.ac.ir/id/eprint/39620

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