Aghamajidi, A. and Raoufi, E. and Parsamanesh, G. and Jalili, A. and Salehi-Shadkami, M. and Mehrali, M. and Mohsenzadegan, M. (2021) The attentive focus on T cell-mediated autoimmune pathogenesis of psoriasis, lichen planus and vitiligo. Scandinavian Journal of Immunology, 93 (4).
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The attentive focus on T cell-mediated autoimmune pathogenesis of psoriasis, lichen planus and vitiligo.pdf Download (1MB) |
Abstract
T cell-mediated autoimmune skin diseases develop as a result of the aberrant immune response to the skin cells with T cells playing a central role. These chronic inflammatory skin diseases encompass various types including psoriasis, lichen planus and vitiligo. These diseases show similarities in their immune-pathophysiology. In the last decade, immunomodulating agents have been very successful in the management of these diseases thanks to a better understanding of the pathophysiology. In this review, we will discuss the immunopathogenic mechanisms and highlight the role of T lymphocytes in psoriasis, lichen planus and vitiligo. This study could provide new insights into a better understanding of targeted therapeutic pathways and biological therapies. © 2020 The Scandinavian Foundation for Immunology
| Item Type: | Article |
|---|---|
| Additional Information: | cited By 1 |
| Uncontrolled Keywords: | antipsoriasis agent; CD4 antigen; CD8 antigen; gamma interferon; interleukin 17; interleukin 21; interleukin 23; monoclonal antibody; tumor necrosis factor, adipocyte; autoimmune skin disease; CD4+ T lymphocyte; CD8+ T lymphocyte; cell differentiation; cell interaction; cell lineage; chondrocyte; cytotoxic T lymphocyte; dendritic cell; depigmentation; epidermal stem cell; Food and Drug Administration; human; immunocompetent cell; keratinocyte; lichen planus; mesenchymal stroma cell; osteoblast; pathogenesis; priority journal; psoriasis; Review; signal transduction; skin fibroblast; stroma cell; T lymphocyte; Th1 cell; Th17 cell; Th22 cell; Th9 cell; vitiligo; animal; autoimmune disease; immunology; lichen planus; psoriasis; skin; T lymphocyte; vitiligo, Animals; Autoimmune Diseases; Humans; Lichen Planus; Psoriasis; Skin; T-Lymphocytes; Vitiligo |
| Subjects: | WR Dermatology QW Microbiology. Immunology |
| Depositing User: | eprints admin |
| Date Deposited: | 09 Nov 2022 08:26 |
| Last Modified: | 09 Nov 2022 08:26 |
| URI: | http://eprints.iums.ac.ir/id/eprint/39646 |
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