The role of Th17 cells in viral infections

Aghbash, P.S. and Hemmat, N. and Nahand, J.S. and Shamekh, A. and Memar, M.Y. and Babaei, A. and Baghi, H.B. (2021) The role of Th17 cells in viral infections. International Immunopharmacology, 91.

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Abstract

The present review provides an overview of recent advances regarding the function of Th17 cells and their produced cytokines in the progression of viral diseases. Viral infections alone do not lead to virus-induced malignancies, as both genetic and host safety factors are also involved in the occurrence of malignancies. Acquired immune responses, through the differentiation of Th17 cells, form the novel components of the Th17 cell pathway when reacting with viral infections all the way from the beginning to its final stages. As a result, instead of inducing the right immune responses, these events lead to the suppression of the immune system. In fact, the responses from Th17 cells during persistent viral infections causes chronic inflammation through the production of IL-17 and other cytokines which provide a favorable environment for tumor growth and its development. Additionally, during the past decade, these cells have been understood to be involved in tumor progression and metastasis. However, further research is required to understand Th17 cells� immune mechanisms in the vast variety of viral diseases. This review aims to determine the roles and effects of the immune system, especially Th17 cells, in the progression of viral diseases; which can be highly beneficial for the diagnosis and treatment of these infections. © 2020 Elsevier B.V.

Item Type: Article
Additional Information: cited By 2
Uncontrolled Keywords: cytokine; interleukin 17, biological functions; BK virus; carcinogenesis; cell differentiation; chronic inflammation; Coronavirinae; Cytomegalovirus; Dengue virus; disease exacerbation; Enterovirus; Epstein Barr virus; Hepatitis A virus; Hepatitis B virus; Hepatitis C virus; Herpes simplex virus; human; Human immunodeficiency virus; Human parvovirus B19; Human respiratory syncytial virus; immune response; immune system; Influenza virus; lymphocyte function; lymphocyte structure; metastasis; Middle East respiratory syndrome coronavirus; nonhuman; priority journal; Review; Rhinovirus; Severe acute respiratory syndrome coronavirus 2; Th17 cell; tumor growth; virus hepatitis; virus infection; Wart virus; animal; host pathogen interaction; immunology; metabolism; neoplasm; pathogenicity; Th17 cell; tumor microenvironment; virology; virus; virus cell transformation; virus infection, Animals; Cell Transformation, Viral; Host-Pathogen Interactions; Humans; Neoplasms; Th17 Cells; Tumor Microenvironment; Tumor Virus Infections; Viruses
Subjects: WC Communicable Diseases
QW Microbiology. Immunology
Depositing User: eprints admin
Date Deposited: 27 Apr 2022 05:55
Last Modified: 02 Nov 2022 10:50
URI: http://eprints.iums.ac.ir/id/eprint/39936

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