Tahvilian, N. and Masoodi, M. and Faghihi Kashani, A. and Vafa, M. and Aryaeian, N. and Heydarian, A. and Hosseini, A. and Moradi, N. and Farsi, F. (2021) Effects of saffron supplementation on oxidative/antioxidant status and severity of disease in ulcerative colitis patients: A randomized, double-blind, placebo-controlled study. Phytotherapy Research, 35 (2). pp. 946-953.
Full text not available from this repository.Abstract
Supplementation with saffron helps improve antioxidant status. Oxidative stress plays an important role in ulcerative colitis (UC). The present study aimed to investigate the effect of saffron supplementation on disease severity and Oxidative/Antioxidant factors in patients with UC. This randomized double-blinded study was conducted on 80 mild to moderate UC patients. Participants were randomly divided into intervention (100 mg saffron/daily) and placebo (100 mg maltodextrin/daily) groups. Of all the participants, 75 completed the study. After 8 weeks, there were significantly increased in the mean score of simple clinical colitis activity index questionnaire (3.83 ± 1.78 to 3 ± 1.60, p =.004), the serum levels of total antioxidant capacity (2.68 ± 0.90 to 2.79 ± 0.87, p =.016), superoxide dismutase (60.69 ± 9.59 to 66.30 ± 10.79, p =.009) and glutathione peroxidase (22.05 ± 14.27 to 29.67 ± 17.97, p =.011) in patients received saffron compared to the placebo group. Whereas, there was no significant difference in serum levels of malondialdehyde between the two groups. Finally, dietary saffron as an alternative therapy may effective in improving antioxidant factors and reducing the severity of disease in UC patients. © 2020 John Wiley & Sons Ltd
| Item Type: | Article |
|---|---|
| Additional Information: | cited By 1 |
| Uncontrolled Keywords: | antioxidant, adult; aged; chemistry; controlled study; Crocus; dietary supplement; double blind procedure; drug effect; female; human; male; middle aged; oxidative stress; randomized controlled trial; ulcerative colitis; young adult, Adult; Aged; Antioxidants; Colitis, Ulcerative; Crocus; Dietary Supplements; Double-Blind Method; Female; Humans; Male; Middle Aged; Oxidative Stress; Young Adult |
| Subjects: | WB Practice of Medicine QV Pharmacology |
| Depositing User: | eprints admin |
| Date Deposited: | 02 Aug 2021 03:43 |
| Last Modified: | 02 Aug 2021 03:43 |
| URI: | http://eprints.iums.ac.ir/id/eprint/39982 |
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