Swept-source OCT angiography imaging of the macular capillary network in glaucoma

Akil, H. and Chopra, V. and Al-Sheikh, M. and Falavarjani, K.G. and Huang, A.S. and Sadda, S.R. and Francis, B.A. (2018) Swept-source OCT angiography imaging of the macular capillary network in glaucoma. British Journal of Ophthalmology, 102 (4). pp. 515-519.

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Purpose To evaluate the macular capillary network density of superficial and deep retinal layers (SRL/DRL) by swept-source optical coherence tomography angiography (OCTA) in patients with primary open angle glaucoma (POAG) and to compare the results with those of normal subjects. Method In this prospective study, 24 eyes of 24 normal individuals and 24 eyes of 24 patients with mild to moderate POAG underwent fovea centred 6�6 mm cube macular OCTA imaging by a swept-source OCTA device (Triton, Topcon, Tokyo, Japan). Quantitative analysis of the retinal vasculature was performed by assessing vessel density (VD) as the ratio of the retinal area occupied by vessels at the SRL and DRL. Results The mean VD (ratio) at the SRL and DRL was statistically significantly lower in patients with POAG (SRL, p<0.001; DRL, p<0.001). In the SRL, the mean±SD VD ratio was 0.34±0.05 in patients with POAG and 0.40±0.02 in normal individuals (p<0.001). In the DRL, the mean (SD) ratio was 0.37±0.05 in patients with POAG and 0.43±0.02 in normal individuals (p<0.001). The mean VD at the SRL was significantly correlated with ganglion cell inner plexiform layer thickness (r=0.42, p=0.04) but not with visual field mean deviation (r=0.4, p=0.06) and retinal nerve fibre layer thickness (r=0.5, p=0.06). The mean VD at the DRL did not show significant correlation with any other glaucoma parameter (p>0.05). Conclusion The assessment of macular VD by swept-source OCTA may offer additional information for detection of glaucoma. © 2018 Article author(s) (or their employer(s) unless otherwise stated in the text of the article). All rights reserved.

Item Type: Article
Additional Information: cited By 0
Depositing User: eprints admin
Date Deposited: 05 Aug 2018 05:24
Last Modified: 30 Sep 2018 09:20
URI: http://eprints.iums.ac.ir/id/eprint/426

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