Peymani, P. and Yeganeh, B. and Sabour, S. and Geramizadeh, B. and Fattahi, M.R. and Keyvani, H. and Azarpira, N. and Coombs, K.M. and Ghavami, S. and Lankarani, K.B. (2016) New use of an old drug: Chloroquine reduces viral and ALT levels in HCV non-responders (a randomized, triple-blind, placebo-controlled pilot trial). Canadian Journal of Physiology and Pharmacology, 94 (6). pp. 613-619.
Full text not available from this repository.Abstract
Hepatitis C virus (HCV) infection induces autophagy, but the virus assimilates the autophagic response into its own life cycle. Chloroquine (CQ) is an autophagy inhibitor that is clinically used to treat malaria. The aims of this pilot clinical trial were to evaluate the therapeutic potential and short-term safety of CQ in patients with chronic HCV genotype 1, who were unresponsive to a combination of pegylated interferon alpha and ribavirin. Ten non-responders to previous antiviral treatment(s) were randomized to receive either CQ (150 mg daily for 8 weeks) or placebo, and were followed for 4 weeks after CQ therapy. HCV RNA load and plasma alanine transaminase (ALT) levels were measured at baseline, week 4 (initial response), week 8 (end-of-treatment response), and at the end of 12 weeks. A significant decrease in HCV RNA after the treatments (week 8) was observed in all patients in the CQ group (P = 0.04). However, HCV RNA levels increased within 4 weeks after discontinuation of CQ treatment although they were still lower than baseline. In addition, the ALT normalized during treatment in the CQ group. However, this response was also lost after treatment cessation. This study provides preliminary evidence that CQ is possibly a safe treatment option for HCV non-responders. � 2016, National Research Council of Canada. All Rights Reserved.
| Item Type: | Article |
|---|---|
| Additional Information: | cited By 2 |
| Depositing User: | eprints admin |
| Date Deposited: | 02 Jul 2018 08:59 |
| Last Modified: | 02 Jul 2018 08:59 |
| URI: | http://eprints.iums.ac.ir/id/eprint/4518 |
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