Karimi, A. and Majidzadeh-A, K. and Madjd, Z. and Akbari, A. and Habibi, L. and Akrami, S.M. (2015) Effect of Copper Sulfate on Expression of Endogenous L1 Retrotransposons in HepG2 Cells (Hepatocellular Carcinoma). Biological Trace Element Research, 165 (2). pp. 131-134.
Full text not available from this repository.Abstract
The long interspersed element-1 (LINE-1 or L1) constitutes approximately 17 of human genome. The expression of these elements is deregulated upon exposure to environmental exposures resulting to genomic instability and cancer promotion. The effect of copper as essential elements in regulation of L1 expression remained to be elucidated. Using non-cytotoxic concentrations of the copper, the expression of endogenous L1 was analyzed by qPCR after 6 days of copper pretreatment in human hepatocellular carcinoma cells (HepG2). The results indicated that the expression of active L1 elements are significantly downregulated at concentrations of 12.5, 25, and 50 μM (p < 0.005). Our data imply that low-level copper exposure may have a protective effect to suppress the induction of L1 activity and decrease incidence of cancer-associated L1 mutagenesis. If this achievement is confirmed by further studies, it can be applied in the long-term goals of cancer prevention. © 2015, Springer Science+Business Media New York.
| Item Type: | Article |
|---|---|
| Additional Information: | cited By 5 |
| Depositing User: | eprints admin |
| Date Deposited: | 02 Jul 2018 08:08 |
| Last Modified: | 02 Jul 2018 08:08 |
| URI: | http://eprints.iums.ac.ir/id/eprint/4897 |
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