Bahadoran, Z. and Mirmiran, P. and Ghasemi, A. and Kabir, A. and Azizi, F. and Hadaegh, F. (2015) Is dietary nitrate/nitrite exposure a risk factor for development of thyroid abnormality? A systematic review and meta-analysis. Nitric Oxide - Biology and Chemistry, 47. pp. 65-76.
Full text not available from this repository.Abstract
The potential effects of inorganic nitrate/nitrite on global health are a much debated issue. In addition to possible methemoglobinemia and carcinogenic properties, anti-thyroid effects of nitrate/nitrite have been suggested. Considering the growing significance of nitrate/nitrite and since there is no comprehensive review in data available, clarifying the effect of nitrate/nitrite on thyroid disorder outcomes is essential. Therefore, we conducted this systematic review of experimental and clinical studies, and a meta-analysis of relevant cohort and cross-sectional studies investigating the association of nitrate/nitrite exposure and thyroid function. Most animal studies show that high exposure (~10-600 times of acceptable daily intake) to nitrate/nitrite induces anti-thyroid effects, including decreased serum level of thyroid hormones and histomorphological changes in thyroid gland; however no similar observations have been documented in humans. Based on our meta-analysis, no significant association was observed between nitrate exposure and the risk of thyroid cancer, hyper- and hypothyroidism; findings from three cohort studies however showed a significant association between higher exposure to nitrite and the risk of thyroid cancer (risk=1.48, 95 confidence interval=1.09-2.02, P=0.012). Additional research is needed to clarify the association between nitrate/nitrite exposures and both thyroid function and cancer. © 2015 Elsevier Inc. All rights reserved.
| Item Type: | Article |
|---|---|
| Additional Information: | cited By 18 |
| Depositing User: | eprints admin |
| Date Deposited: | 02 Jul 2018 08:02 |
| Last Modified: | 02 Jul 2018 08:02 |
| URI: | http://eprints.iums.ac.ir/id/eprint/4940 |
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