Jamilian, M. and Shojaei, A. and Samimi, M. and Afshar Ebrahimi, F. and Aghadavod, E. and Karamali, M. and Taghizadeh, M. and Jamilian, H. and Alaeinasab, S. and Jafarnejad, S. and Asemi, Z. (2018) The effects of omega-3 and vitamin E co-supplementation on parameters of mental health and gene expression related to insulin and inflammation in subjects with polycystic ovary syndrome. Journal of Affective Disorders, 229. pp. 41-47.
Full text not available from this repository.Abstract
Objective The aim of this study was to evaluate the effects of omega-3 and vitamin E co-supplementation on parameters of mental health and gene expression related to insulin and inflammation in subjects with polycystic ovary syndrome (PCOS). Methods Forty PCOS women were allocated into two groups and treated with 1000 mg omega-3 fatty acids plus 400 IU vitamin E supplements (n = 20) or placebo (n = 20) per day for 12 weeks. Parameters of mental health were recorded at baseline and after the 12-week intervention. Gene expression related to insulin and inflammation were measured in blood samples of PCOS women. Results After the 12-week intervention, compared with the placebo, omega-3 and vitamin E co-supplementation led to significant improvements in beck depression inventory total score (� 2.2 ± 2.0 vs. � 0.2 ± 1.3, P = 0.001), general health questionnaire scores (� 5.5 ± 4.6 vs. � 1.0 ± 2.3, P < 0.001) and depression anxiety and stress scale scores (� 7.2 ± 5.2 vs. � 1.3 ± 1.3, P < 0.001). Compared with the placebo, omega-3 and vitamin E co-supplementation could up-regulate peroxisome proliferator-activated receptor gamma (PPAR-γ) expression (P = 0.04) in peripheral blood mononuclear cells (PBMC) of PCOS women. In addition, compared with the placebo, omega-3 and vitamin E co-supplementation down-regulated interleukin-8 (IL-8) (P = 0.003) and tumor necrosis factor alpha (TNF-α) expression (P = 0.001) in PBMC of PCOS women. There were no significant difference between-group changes in glucose transporter 1 (GLUT-1), IL-6 and transforming growth factor beta (TGF-β) in PBMC of PCOS women. Conclusion Omega-3 and vitamin E co-supplementation was effective in improving parameters of mental health, and gene expression of PPAR-γ IL-8 and TNF-α of women with PCOS. © 2017 Elsevier B.V.
| Item Type: | Article |
|---|---|
| Additional Information: | cited By 1 |
| Depositing User: | eprints admin |
| Date Deposited: | 05 Aug 2018 04:55 |
| Last Modified: | 05 Aug 2018 04:55 |
| URI: | http://eprints.iums.ac.ir/id/eprint/509 |
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