Shahidi, M. and Vatanmakanian, M. and Arami, M.K. and Sadeghi Shirazi, F. and Esmaeili, N. and Hydarporian, S. and Jafari, S. (2018) A comparative study between platelet-rich plasma and platelet-poor plasma effects on angiogenesis. Medical Molecular Morphology, 51 (1). pp. 21-31.
Full text not available from this repository.Abstract
Platelet-rich plasma (PRP) has been established as an autologous source for therapeutic angiogenesis. The purpose of this study was to evaluate PRP angiogenic effects compared to platelet-poor plasma (PPP) in vitro and in vivo. The effects of PRP on vascular endothelial growth factor receptor-2 (VEGFR2) and CD34 expression were evaluated using real-time PCR, flow cytometry, western blot, immunocytochemistry and pathological study, as were carried out in both human umbilical endothelial cell culture and rat skin. Our findings indicated significant effect of PRP and PPP on VEGFR2 and CD34 expression by human umbilical vein endothelial cells, which was greater in latter. These effects, however, were confirmed by demonstrating an earlier angiogenic effect of PPP in vivo when compared to PRP. The findings of the present study as the first comparative study of PRP versus PPP are novel. Nevertheless, further studies are needed to clarify the underlying mechanism of these findings to improve the therapeutic effects of PRP and PPP. © 2017, The Japanese Society for Clinical Molecular Morphology.
| Item Type: | Article |
|---|---|
| Additional Information: | cited By 0 |
| Depositing User: | eprints admin |
| Date Deposited: | 05 Aug 2018 04:51 |
| Last Modified: | 05 Aug 2018 04:51 |
| URI: | http://eprints.iums.ac.ir/id/eprint/540 |
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