Post-treatment of melatonin with CCl4 better reduces fibrogenic and oxidative changes in liver than melatonin co-treatment

Mortezaee, K. and Majidpoor, J. and Daneshi, E. and Abouzaripour, M. and Abdi, M. (2018) Post-treatment of melatonin with CCl4 better reduces fibrogenic and oxidative changes in liver than melatonin co-treatment. Journal of Cellular Biochemistry, 119 (2). pp. 1716-1725.

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Therapeutic effects of melatonin (MEL) in targeting CCl4-induced liver fibrosis has been widely known, but there is no study comparing oxidative and fibrogenic changes in co- and post-treatment of MEL with CCl4, which was further aimed in this experiment. Male SD rats were injected with CCl4 (1 mL/kg/i.p./daily) dissolved 1:1 in olive oil for 1 month. Some animals received MEL (20 mg/kg/i.p./daily) diluted in 1 mL PBS in combination with CCl4 (co-treatment), and some rats were treated with MEL, beginning with injection of the last dose of CCl4 for one month (post-treatment). The groups were control, CCl4, CCl4-co vehicle, CCl4-post vehicle, post-CCl4, MEL co-treatment, and MEL post-treatment. MEL post-treatment group showed significantly lower lipid deposition, serum malondialdehyde (MDA), serum alanine aminotransferase (ALT), and liver hydroxyproline. This group also had low expressions of Bax and transforming growth factor-β1 (TGF-β1). MEL post-treatment group revealed higher sera levels of albumin, superoxide dismutase (SOD) and glutathione peroxidase (GPx). Expression levels of metalloproteinase-13 (MMP-13) and Bcl2 was also higher in this group (P � 0.05 vs co-treatment). Results of the present study indicated that MEL post-treatment is more powerful in reduction of CCl4-induced liver fibrosis through reduction of oxidative stress and maintenance of matrix balance. © 2017 Wiley Periodicals, Inc.

Item Type: Article
Additional Information: cited By 4
Uncontrolled Keywords: alanine aminotransferase; albumin; beta actin; carbon tetrachloride; collagenase 3; glutathione peroxidase; hydroxyproline; lipid; m 5250 1g; malonaldehyde; melatonin; protein Bax; protein bcl 2; superoxide dismutase; transforming growth factor beta1, alanine aminotransferase blood level; albumin blood level; animal cell; animal experiment; animal model; animal tissue; Article; blood level; carbon tetrachloride-induced liver fibrosis; comparative study; controlled study; dosage schedule comparison; enzyme blood level; fibrogenesis; lipid storage; liver level; liver tissue; male; nonhuman; oxidative stress; priority journal; protein blood level; protein expression; rat
Subjects: WK Endocrine System
Depositing User: eprints admin
Date Deposited: 29 Dec 2018 10:57
Last Modified: 29 Dec 2018 10:57

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