Badehnoosh, B. and Karamali, M. and Zarrati, M. and Jamilian, M. and Bahmani, F. and Tajabadi-Ebrahimi, M. and Jafari, P. and Rahmani, E. and Asemi, Z. (2018) The effects of probiotic supplementation on biomarkers of inflammation, oxidative stress and pregnancy outcomes in gestational diabetes. Journal of Maternal-Fetal and Neonatal Medicine, 31 (9). pp. 1128-1136.
Full text not available from this repository.Abstract
Objective: This study was designed to evaluate the effects of probiotic supplementation on biomarkers of inflammation, oxidative stress and pregnancy outcomes among subjects with gestational diabetes (GDM). Methods: This randomized, double-blind, placebo-controlled clinical trial was done among 60 subjects with GDM who were not on oral hypoglycemic agents. Patients were randomly allocated to intake either probiotic capsule containing Lactobacillus acidophilus, Lactobacillus casei and Bifidobacterium bifidum (2 � 109 CFU/g each) (n = 30) or placebo (n = 30) for six weeks. Results: Compared with the placebo, probiotic supplementation resulted in significant decreases in fasting plasma glucose (FPG) (�5.3 ± 6.7 vs. +0.03 ± 9.0 mg/dL, p =.01), serum high-sensitivity C-reactive protein (hs-CRP) (�2.2 ± 2.7 vs. +0.5 ± 2.4 μg/mL, p <.001), plasma malondialdehyde (MDA) concentrations (�0.1 ± 0.8 vs. +0.5 ± 1.5 μmol/L, p =.03) and MDA/TAC ratio (�0.0003 ± 0.0008 vs. +0.0009 ± 0.002, p =.004), and a significant increase in total antioxidant capacity (TAC) levels (+65.4 ± 103.3 vs. �37.2 ± 143.7 mmol/L, p =.002). Probiotic supplementation did not affect pregnancy outcomes. Conclusions: Overall, probiotic supplementation among women with GDM for six weeks had beneficial effects on FPG, serum hs-CRP, plasma TAC, MDA and oxidative stress index, but did not affect pregnancy outcomes. © 2017 Informa UK Limited, trading as Taylor & Francis Group.
| Item Type: | Article |
|---|---|
| Additional Information: | cited By 3 |
| Uncontrolled Keywords: | biological marker; C reactive protein; glucose; glutathione; malonaldehyde; nitric oxide; placebo; probiotic agent; biological marker; C reactive protein; malonaldehyde; probiotic agent, adult; antioxidant assay; Article; bacterial strain; Bifidobacterium bifidum; body height; body mass; body weight; clinical assessment; comparative study; controlled study; dietary intake; double blind procedure; female; glucose blood level; human; inflammation; Lactobacillus acidophilus; Lactobacillus casei; major clinical study; medication compliance; oxidative stress; patient compliance; pregnancy diabetes mellitus; pregnancy outcome; priority journal; protein blood level; randomized controlled trial; supplementation; treatment duration; analysis; blood; dietary supplement; inflammation; oxidative stress; physiology; pregnancy; pregnancy diabetes mellitus, Adult; Biomarkers; Blood Glucose; C-Reactive Protein; Diabetes, Gestational; Dietary Supplements; Double-Blind Method; Female; Humans; Inflammation; Malondialdehyde; Oxidative Stress; Placebos; Pregnancy; Pregnancy Outcome; Probiotics |
| Subjects: | WP Gynecology QV Pharmacology |
| Depositing User: | eprints admin |
| Date Deposited: | 26 Dec 2018 13:34 |
| Last Modified: | 26 Dec 2018 13:34 |
| URI: | http://eprints.iums.ac.ir/id/eprint/5909 |
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